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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Near full-length genome analysis of HCV genotype 5 strains from South Africa
Infection, Genetics and Evolution, Volume 21, Year 2014
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Description
Hepatitis C virus (HCV) genotype 5 is the predominant genotype in South Africa. However, to date, only 2 full-length genotype 5 genomes have been sequenced and only one is from South Africa. This study characterized HCV genotype 5 sequences from South Africa, including six near full-length genomes, as well as the E1 region from an additional 12 genotype 5 samples. Phylogenetic analysis of these near full-length genome sequences revealed that all genotype 5 sequences formed a close cluster with high bootstrap support. Bayesian analysis of the E1 region was used to estimate the time of the most recent common ancestor (tMRCA). The tMRCA for HCV genotype 5a was estimated at 114-134. years before the last sampling date. In conclusion, this study provides six near full-length genotype 5 nucleotide sequences for use as references to design efficient vaccines and for the development of new antiviral agents, and provides further insight into the diversity of HCV genotypes circulating in South Africa. © 2013 Elsevier B.V.
Authors & Co-Authors
Gededzha, Maemu Petronella
South Africa, Sovenga
University of Limpopo
Selabe, Selokela Gloria
South Africa, Sovenga
University of Limpopo
Blackard, Jason Tory
United States, Cincinnati
University of Cincinnati College of Medicine
Kyaw, Thanda
South Africa, Sovenga
University of Limpopo
Mphahlele, M. Jeffrey
South Africa, Sovenga
University of Limpopo
Statistics
Citations: 19
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1016/j.meegid.2013.10.022
ISSN:
15671348
e-ISSN:
15677257
Research Areas
Genetics And Genomics
Infectious Diseases
Study Locations
South Africa