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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Self-expanding metal stenting for palliation of patients with malignant colonic obstruction: Effectiveness and efficacy on 255 patients with 12-month's follow-up
Gastroenterology Research and Practice, Article 296347, Year 2012
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Description
Background. Self-expanding metal stents can alleviate malignant colonic obstruction in incurable patients and avoid palliative stoma surgery. Objective. Evaluate stent effectiveness and safety on palliation of patients with malignant colorectal strictures. Design. Two prospective, one Spanish and one global, multicenter studies. Settings. 39 centers (22 academic, 17 community hospitals) from 13 countries. Patients. A total of 257 patients were enrolled, and 255 patients were treated with a WallFlex uncovered enteral colonic stent. Follow-up was up to 12 months or until death or retreatment. Interventions(s). Self-expanding metal stent placement. Main Outcome Measures. Procedural success, clinical success, and safety. Results. Procedural success was 98.4 (251). Clinical success rates were 87.8 at 30 days, 89.7 at 3 months, 92.8 at 6 months, and 96 at 12 months. Overall perforation rate was 5.1. Overall migration rate was 5.5. Overall death rate during follow-up was 48.6 (124), with 67.7 of deaths related to the patient's colorectal cancer, unrelated in 32.3. Only 2 deaths were related to the stent or procedure. Limitations. No control group. Conclusions. The primary palliative option for patients with malignant colonic obstruction should be self-expanding metal stent placement due to high rates of technical success and efficacy in symptom palliation and few complications. Copyright © 2012 Sren Meisner et al.
Authors & Co-Authors
Meisner, Søren
Denmark, Copenhagen
Bispebjerg Hospital
González-Huix, Ferran
Spain, Girona
Hospital Universitari de Girona Dr. Josep Trueta
Vandervoort, Jo G.
Belgium, Aalst
Onze Lieve Vrouw Hospital
Repici, Alessandro
Italy, Rozzano
Humanitas Research Hospital
Xinopoulos, Dimitrios
Greece, Athens
Saint Savvas Hospital
Grund, Karl E.
Germany, Tubingen
Universitätsklinikum Und Medizinische Fakultät Tübingen
Goldberg, Paul A.
South Africa, Observatory
Groote Schuur Hospital
Statistics
Citations: 31
Authors: 7
Affiliations: 7
Identifiers
Doi:
10.1155/2012/296347
ISSN:
16876121
e-ISSN:
1687630X
Research Areas
Cancer
Health System And Policy
Study Design
Randomised Control Trial
Cohort Study