Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
The expression and function of NKG2D molecule on intrahepatic CD8+ T cells in chronic viral hepatitis
Journal of Viral Hepatitis, Volume 15, No. 12, Year 2008
Notification
URL copied to clipboard!
Description
The natural killer (NK) cell receptor, NKG2D is a member of the c-type lectin-activating receptor family. It is expressed by all NK cells and by a sub-population of CD8+ T cells. NKG2D engagement with its ligands directly activates NK cells and acts as a co-stimulator on CD8+ T cells. Recent reports, however, have demonstrated a role for NKG2D in direct T-cell activation in chronic inflammation. The aim of this study was to investigate the pattern of expression and the functional role of NKG2D on circulating and intrahepatic CD8+ T cells in chronic viral hepatitis. Peripheral blood lymphocytes and intrahepatic lymphocytes from 45 patients with chronic viral hepatitis (HBV and HCV) were studied. Phenotypic NKG2D expression and its functional ability to activate intrahepatic and circulating lymphocytes were analysed. Intrahepatic CD8+ T cells display increased NKG2D expression in chronic viral hepatitis in comparison with circulating CD8+ T cells. NKG2D co-stimulates intrahepatic CD8+ T cells and hepatitis B virus-specific CD8+ T cells. However, we could not demonstrate an ability to directly activate CD8+ T cells through the NKG2D signalling pathway alone. NKG2D is up-regulated on intrahepatic CD8+ T cells in type B and C chronic viral hepatitis; however, its function appears to be restricted to that of a co-stimulatory molecule. © 2008 The Authors.
Authors & Co-Authors
Kennedy, Patrick T.F.
United Kingdom, London
University College London
United Kingdom, London
The Royal Free Hospital
Gehring, Adam J.
United Kingdom, London
University College London
Singapore, Singapore City
A-star, Singapore Institute for Clinical Sciences
Selden, Clare A.
United Kingdom, London
The Royal Free Hospital
Quaglia, Alberto Felice
United Kingdom, London
King's College Hospital
Dhillon, A. P.
United Kingdom, London
The Royal Free Hospital
Dusheiko, Geoffrey M.
United Kingdom, London
The Royal Free Hospital
Bertoletti, Antonio
United Kingdom, London
University College London
Singapore, Singapore City
A-star, Singapore Institute for Clinical Sciences
Statistics
Citations: 19
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1111/j.1365-2893.2008.01049.x
ISSN:
13652893
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study