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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Antipyretic properties of the aqueous and ethanol extracts of the leaves of Ocimum suave and Ocimum lamiifolium in mice
Journal of Ethnopharmacology, Volume 88, No. 1, Year 2003
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Description
Numerous plant species are used to treat ailments associated with pyrexia in the indigenous health care delivery system of Ethiopia. Notable among these are Ocimum suave and Ocimum lamiifolium. The objective of the present study was thus to evaluate the antipyretic effects of the aqueous and ethanol extracts of the leaves of Ocimum suave and Ocimum lamiifolium in mice. Rectal temperatures were recorded before and after inducing pyrexia as well as after administration of the respective extracts every half an hour for 3 h. Parallel experiments were run with a standard antipyretic (acetylsalicylic acid) and the vehicle (distilled water). All the plant extracts showed antipyretic property with reasonable onset and duration of action. Both ethanol and aqueous extracts of Ocimum suave were observed to be more potent than those of Ocimum lamiifolium. Aqueous extract of Ocimum suave and ethanol extract of Ocimum lamiifolium were more potent than their other counterpart extracts. Time dependent antipyretic effect was also observed with some extracts; reduced with time with aqueous extract of Ocimum suave and increased with time with both extracts of Ocimum lamiifolium. © 2003 Elsevier Ireland Ltd. All rights reserved.
Authors & Co-Authors
Makonnen, Eyasu
Ethiopia, Addis Ababa
School of Medicine
Debella, Asfaw
Ethiopia, Addis Ababa
Ethiopian Public Health Institute
Zerihun, Legesse
Ethiopia, Addis Ababa
School of Medicine
Abebe, Dawit
Ethiopia, Addis Ababa
Ethiopian Public Health Institute
Teka, Frehiwot
Ethiopia, Addis Ababa
Ethiopian Public Health Institute
Statistics
Citations: 70
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1016/S0378-8741(03)00175-2
ISSN:
03788741
Research Areas
Environmental
Study Locations
Ethiopia