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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Molecular epidemiology of group A rotavirus in Buenos Aires, Argentina 2004-2007: Reemergence of G2P[4] and emergence of G9P[8] strains
Journal of Medical Virology, Volume 82, No. 6, Year 2010
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Description
Detection and characterization of group A rotavirus in Buenos Aires, Argentina, was conducted on 710 fecal samples from children 0-15 years old collected between 2004 and 2007. Rotavirus was detected in 140 (19.7%) samples with G9P[8] (30.0%) and G2P[4] (21.4%) as the most common genotypes. Mixed (G and/or P) infections accounted for 17.9% of the samples and the emerging G12 strain was detected during 2004 (3.5%) and 2007 (2.5%). Genotype G2 was the most prevalent during 2004 (43.9%) and 2007 (57.5%) and G9 during 2005 (58.0%) and 2006 (61.5%). Analysis of genotype prevalences from studies performed since 1996 in the samearea showed striking natural fluctuations in G and P genotype frequencies. In particular, G2P[4] strains disappeared after 1999 and reemerged in2004 to become the predominant strain by 2007 with a concomitant major decrease in G1P[8] prevalence. The VP7 genes from Argentinian G9 and G2 strains were sequenced and phylogenetic analysis was conducted in order to compare with sequences from strains isolated in regional countries reported previously. Several changes in the deduced amino acid sequence in antigenic regions of the VP7 protein from Argentinian and Brazilian strains were identified compared to vaccine strains. Overall, this study revealed relationships in the circulation of rotavirus strains in South American countries and major replacements in dominant genotypes, including the virtual disappearance of G1P[8] strains in a non-vaccinated population. High numbers of mixed infections speeding up evolution, circulation of rare serotypes, and antigenic drift could, eventually,become challenges for new vaccines. © 2010 Wiley-Liss, Inc.
Authors & Co-Authors
Gentsch, Jon R.
United States, Washington, D.c.
United States Department of Health and Human Services
Jiang, Baoming
United States, Washington, D.c.
United States Department of Health and Human Services
Esona, Mathew Dioh
United States, Washington, D.c.
United States Department of Health and Human Services
Glass, Roger I.M.
United States, Washington, D.c.
United States Department of Health and Human Services
United States, Bethesda
Fogarty International Center
Statistics
Citations: 51
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1002/jmv.21745
ISSN:
10969071
Research Areas
Genetics And Genomics
Maternal And Child Health
Study Design
Cross Sectional Study