Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Production of induced secondary metabolites by a co-culture of sponge-associated actinomycetes, Actinokineospora sp. EG49 and Nocardiopsis sp. RV163
Marine Drugs, Volume 12, No. 5, Year 2014
Notification
URL copied to clipboard!
Description
Two sponge-derived actinomycetes, Actinokineospora sp. EG49 and Nocardiopsis sp. RV163, were grown in co-culture and the presence of induced metabolites monitored by 1H NMR. Ten known compounds, including angucycline, diketopiperazine and β-carboline derivatives 1-10, were isolated from the EtOAc extracts of Actinokineospora sp. EG49 and Nocardiopsis sp. RV163. Co-cultivation of Actinokineospora sp. EG49 and Nocardiopsis sp. RV163 induced the biosynthesis of three natural products that were not detected in the single culture of either microorganism, namely N-(2-hydroxyphenyl)- acetamide (11), 1,6-dihydroxyphenazine (12) and 5a,6,11a,12-tetrahydro-5a,11a- dimethyl[1,4]benzoxazino[3,2-b][1,4]benzoxazine (13a). When tested for biological activity against a range of bacteria and parasites, only the phenazine 12 was active against Bacillus sp. P25, Trypanosoma brucei and interestingly, against Actinokineospora sp. EG49. These findings highlight the co-cultivation approach as an effective strategy to access the bioactive secondary metabolites hidden in the genomes of marine actinomycetes. © 2014 by the authors; licensee MDPI.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4052330/bin/marinedrugs-12-03046-s001.pdf
Authors & Co-Authors
Dashti, Yousef
Australia, Brisbane
Griffith University
Grkovic, Tanja
Australia, Brisbane
Griffith University
Abdelmohsen, Usama Ramadan
Germany, Wurzburg
Biozentrum Der Universität Würzburg
Egypt, Minya
Faculty of Pharmacy
Hentschel, Ute
Germany, Wurzburg
Biozentrum Der Universität Würzburg
Quinn, Ronald J.
Australia, Brisbane
Griffith University
Statistics
Citations: 110
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.3390/md12053046
e-ISSN:
16603397
Research Areas
Health System And Policy