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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Molecular characterisation of a coxsackievirus A24 that caused an outbreak of acute haemorrhagic conjunctivitis, Tunisia 2003
Clinical Microbiology and Infection, Volume 13, No. 2, Year 2007
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Description
This study reports the genetic characteristics of coxsackievirus A24 isolates from Tunisia, including a coxsackievirus A24 variant (CVA24v) that caused an outbreak of acute haemorrhagic conjunctivitis (AHC) between September and November 2003. The virus genome was detected by PCR from conjunctival swabs obtained from patients with AHC. Four virus isolates were obtained from PCR-positive samples and were serotyped by sequence analysis of the VP1 and VP4 genomic region and by seroneutralisation. Phylogenetic analysis of the VP1, VP4 and 3C genomic regions was performed. Other Tunisian CVA24 isolates from paralytic cases and healthy individuals were also amplified, sequenced and included in the phylogenetic analysis. The epidemic strain belonged to the CVA24 serotype. Phylogenetic analysis of the 3C region of the genome revealed a strong relationship between the Tunisian epidemic strain and strains that caused outbreaks in Korea (2002) and Guadeloupe and French Guiana (2003). Phylogenetic analysis of the VP1 and VP4 regions showed a clear distinction between serotype CVA24 isolates from conjunctivitis and non-conjunctivitis cases. This is the first study to report an outbreak of AHC caused by CVA24v in the North African region. © 2007 European Society of Clinical Microbiology and Infectious Diseases.
Authors & Co-Authors
Triki, Henda
Tunisia, Tunis
Institut Pasteur de Tunis
Rezig, Dorra
Tunisia, Tunis
Institut Pasteur de Tunis
Bahri, Olfa
Tunisia, Tunis
Institut Pasteur de Tunis
Ben Ayed, Narjess
Tunisia, Tunis
Institute of Ophthalmology
Ben-Yahia, Ahlem
Tunisia, Tunis
Institut Pasteur de Tunis
Sadraoui, Amel
Tunisia, Tunis
Institut Pasteur de Tunis
Ayed, Saïda
Tunisia, Tunis
Institute of Ophthalmology
Statistics
Citations: 22
Authors: 7
Affiliations: 2
Identifiers
Doi:
10.1111/j.1469-0691.2006.01618.x
ISSN:
1198743X
e-ISSN:
14690691
Research Areas
Genetics And Genomics
Study Locations
Tunisia