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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Neutralizing antibody responses in acute human immunodeficiency virus type 1 subtype C infection
Journal of Virology, Volume 81, No. 12, Year 2007
Notification
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Description
The study of the evolution and specificities of neutralizing antibodies during the course of human immunodeficiency virus type 1 (HIV-1) infection may be important in the discovery of possible targets for vaccine design. In this study, we assessed the autologous and heterologous neutralization responses of 14 HIV-1 subtype C-infected individuals, using envelope clones obtained within the first 2 months postinfection. Our data show that potent but relatively strain-specific neutralizing antibodies develop within 3 to 12 months of HIV-1 infection. The magnitude of this response was associated with shorter V1-to-V5 envelope lengths and fewer glycosylation sites, particularly in the V1-V2 region. Anti-MPER antibodies were detected in 4 of 14 individuals within a year of infection, while antibodies to CD4-induced (CD4i) epitopes developed to high titers in 12 participants, in most cases before the development of autologous neutralizing antibodies. However, neither anti-MPER nor anti-CD4i antibody specificity conferred neutralization breadth. These data provide insights into the kinetics, potency, breadth, and epitope specificity of neutralizing antibody responses in acute HIV-1 subtype C infection. Copyright © 2007, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Gray, Elin Solomonovna
South Africa, Johannesburg
National Institute for Communicable Diseases
Moore, Penny L.
South Africa, Johannesburg
National Institute for Communicable Diseases
Choge, Isaac A.
South Africa, Johannesburg
National Institute for Communicable Diseases
Decker, Julie M.
United States, Birmingham
The University of Alabama at Birmingham
Bibollet-Ruche, Frédéric
United States, Birmingham
The University of Alabama at Birmingham
Li, Hui
United States, Birmingham
The University of Alabama at Birmingham
Leseka, N.
South Africa, Johannesburg
National Institute for Communicable Diseases
Treurnicht, F. K.
South Africa, Cape Town
University of Cape Town
Mlisana, Koleka P.
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
Shaw, George M.
United States, Birmingham
The University of Alabama at Birmingham
Abdool Karim, Salim S.
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
Williamson, Carolyn
South Africa, Cape Town
University of Cape Town
Morris, Lynn
South Africa, Johannesburg
National Institute for Communicable Diseases
Statistics
Citations: 327
Authors: 13
Affiliations: 4
Identifiers
Doi:
10.1128/JVI.00239-07
ISSN:
0022538X
Research Areas
Infectious Diseases