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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Immune depression in bovine trypanosomiasis: effects of acute and chronic Trypanosoma congolense and chronic Trypanosoma vivax infections on antibody response to Brucella abortus vaccine
Parasite Immunology, Volume 5, No. 3, Year 1983
Notification
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Description
Summary Cattle were vaccinated with Brucella abortus (S19) vaccine during acute (25 days) and chronic (25 weeks) Trypanosoma congolense and chronic Trypanosoma vivax (25 weeks) infections in order to determine the effect of such infections on the antibody response to the vaccine. It was found that the specific antibody responses of IgG1 and IgG2 sub‐classes were profoundly depressed (80%) in both the acute and chronic infections with T. congolense. Whereas IgM antibody response was also profoundly depressed (90%) in cattle with the acute infection, it was only 50% depressed in those with chronic infection. There was no depression of IgG1, IgG2, or IgM in cattle infected with T. vivax. These animals, however, had no detectable parasitaemia at the time of vaccination and thereafter. These results suggest that during acute infection with T. congolense depressive mechanisms could be acting on the afferent arm of the immune response, namely, antigen recognition and/or processing. Copyright © 1983, Wiley Blackwell. All rights reserved
Authors & Co-Authors
Rurangirwa, Fred R.
Kenya, Nairobi
International Laboratory for Research on Animal Diseases, Kenya
Musoke, Anthony Jim Tony
Kenya, Nairobi
International Laboratory for Research on Animal Diseases, Kenya
Nantulya, Vinand M.
Kenya, Nairobi
International Laboratory for Research on Animal Diseases, Kenya
Tabel, Henry
Canada, Saskatoon
University of Saskatchewan, Western College of Veterinary Medicine
Statistics
Citations: 61
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1111/j.1365-3024.1983.tb00743.x
ISSN:
01419838
e-ISSN:
13653024
Research Areas
Mental Health