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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Development and testing of a de novo clinical staging system for podoconiosis (endemic non-filarial elephantiasis)
Tropical Medicine and International Health, Volume 13, No. 10, Year 2008
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Description
Objective: To develop and test a robust clinical staging system for podoconiosis, a geochemical disease in individuals exposed to red clay soil. Methods: We adapted the Dreyer system for staging filarial lymphoedema and tested it in four re-iterative field tests conducted in an area of high-podoconiosis prevalence in Southern Ethiopia. The system has five stages according to proximal spread of disease and presence of dermal nodules, ridges and bands. We measured the 1-week repeatability and the inter-observer agreement of the final staging system. Results: The five-stage system is readily understood by community workers with little health training. Kappa for 1-week repeatability was 0.88 (95% CI 0.80-0.96), for agreement between health professionals was 0.71 (95% CI 0.60-0.82), while that between health professionals and community podoconiosis agents without formal health training averaged 0.64 (95% CI 0.52-0.78). Conclusions: This simple staging system with good inter-observer agreement and repeatability can assist in the management and further study of podoconiosis. © 2008 Blackwell Publishing Ltd.
Authors & Co-Authors
Tekola-Ayele, Fasil
United Kingdom, Brighton
Brighton and Sussex Medical School
Ayele, Zewdu Berhanie
Ethiopia, Addis Ababa
All Africa Leprosy, Tuberculosis and Rehabilitation Training Centre Addis Ababa
Mariam, Dereje Haile
Ethiopia
Otona Hospital
Fuller, Claire
United Kingdom, Canterbury
East Kent Hospitals University Nhs Foundation Trust
Davey, G. J.G.
Ethiopia, Addis Ababa
Addis Ababa University
Statistics
Citations: 78
Authors: 5
Affiliations: 5
Identifiers
Doi:
10.1111/j.1365-3156.2008.02133.x
ISSN:
13602276
e-ISSN:
13653156
Study Design
Cross Sectional Study
Study Locations
Ethiopia