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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Erythrocyte CR1 expression level does not correlate with a HindIII restriction fragment length polymorphism in Africans; implications for studies on malaria susceptibility
Genes and Immunity, Volume 3, No. 8, Year 2002
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Description
Complement receptor 1 (CR1) expression level on erythrocytes is genetically determined, and in Caucasian populations is linked to high (H) and low (L) expression alleles identified by a HindIII restriction fragment length polymorphism (RFLP). Erythrocyte CR1 may be an important factor in determining malaria susceptibility, as low expression of CR1 reduces the rosetting of uninfected erythrocytes with Plasmodium falciparum-infected cells, a process that contributes to malaria pathogenesis. Prior to studying CR1 expression and malaria susceptibility, we have investigated whether the quantity of erythrocyte CR1 correlates with the H and L alleles in an African population. Mean erythrocyte CR1 in 149 Malian adults was 415 molecules per cell, which is comparable to Caucasian populations; however, there was no relationship between erythrocyte CR1 level and genotype for the HindIII RFLP (mean CR1 per erythrocyte HH = 414, HL = 419 and LL = 403, P > 0.1, Student's t-test). The conclusions of a previous study of erythrocyte CR1 expression level and malaria susceptibility in West Africa that was based on HindIII RFLP genotyping may therefore need to be re-evaluated. © 2002 Nature Publishing Group. All rights reserved.
Authors & Co-Authors
Rowe, Jane Alexandra
United Kingdom, Edinburgh
The University of Edinburgh
United Kingdom, Edinburgh
Institute of Cell, Animal and Population Biology
Raza, Ahmed J.
United Kingdom, Edinburgh
The University of Edinburgh
Diallo, Dapa Aly
Mali, Bamako
University of Bamako
Baby, Mounirou A.
Mali, Bamako
University of Bamako
Poudiougo, B.
Mali, Bamako
University of Bamako
Coulibaly, Drissa M.
Mali, Bamako
University of Bamako
Cockburn, I. A.
United Kingdom, Edinburgh
The University of Edinburgh
Middleton, J. J.
United States, Philadelphia
Drexel University College of Medicine
Lyke, Kirsten E.
United States, Baltimore
University of Maryland, Baltimore Umb
Plowe, Christopher Vv
United States, Baltimore
University of Maryland, Baltimore Umb
Doumbo, Ogobara K.
Mali, Bamako
University of Bamako
Moulds, Joann M.
United States, Philadelphia
Drexel University College of Medicine
Statistics
Citations: 53
Authors: 12
Affiliations: 5
Identifiers
Doi:
10.1038/sj.gene.6363899
ISSN:
14664879
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Multi-countries