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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Multiple oncogenic viruses identified in Ocular surface squamous neoplasia in HIV-1 patients
Infectious Agents and Cancer, Volume 5, No. 1, Article 6, Year 2010
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Description
Background: Ocular surface squamous neoplasia (OSSN) is a rare cancer that has increased in incidence with the HIV pandemic in Africa. The underlying cause of this cancer in HIV-infected patients from Botswana is not well defined. Results. Tissues were obtained from 28 OSSN and 8 pterygia patients. The tissues analyzed from OSSN patients were 83% positive for EBV, 75% were HPV positive, 70% were KSHV positive, 75% were HSV-1/2 positive, and 61% were CMV positive by PCR. Tissues from pterygium patients were 88% positive for EBV, 75% were HPV positive, 50% were KSHV positive, and 60% were CMV positive. None of the patients were JC or BK positive. In situ hybridization and immunohistochemistry analyses further identified HPV, EBV, and KSHV in a subset of the tissue samples. Conclusion. We identified the known oncogenic viruses HPV, KSHV, and EBV in OSSN and pterygia tissues. The presence of these tumor viruses in OSSN suggests that they may contribute to the development of this malignancy in the HIV population. Further studies are necessary to characterize the molecular mechanisms associated with viral antigens and their potential role in the development of OSSN. © 2010 Simbiri et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Simbiri, Kenneth Omollo A.
United States, Philadelphia
Penn Medicine
Murakami, Masanao
Japan, Nankoku
Kochi Medical School
Feldman, Michael D.
United States, Philadelphia
Pathology and Laboratory Medicine
Steenhoff, Andrew P.
United States, Philadelphia
Botswana-upenn Partnership
Nkomazana, O. F.
Botswana, Gaborone
University of Botswana
Bisson, Gregory P.
United States, Philadelphia
Center for Clinical Epidemiology and Biostatistics
Robertson, Erle S.
United States, Philadelphia
Penn Medicine
Statistics
Citations: 45
Authors: 7
Affiliations: 6
Identifiers
Doi:
10.1186/1750-9378-5-6
e-ISSN:
17509378
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Botswana