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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Endemic Malagasy Dalbergia species inhibit quorum sensing in Pseudomonas aeruginosa PAO1
Microbiology (United Kingdom), Volume 159, No. PART 5, Year 2013
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Description
Various species of the plant genus Dalbergia are traditionally used as medicine for sundry ailments and some of them have been shown recently to quench the virulence of Gram-positive and Gram-negative bacteria. Cell-to-cell communication mechanisms, quorum sensing (QS) in particular, are key regulators of virulence in many pathogenic bacteria. Screening n-hexane extracts of leaves, roots and bark of endemic Malagasy Dalbergia species for their capacity to antagonize QS mechanisms in Pseudomonas aeruginosa PAO1 showed that many reduced the expression of the QS-regulated genes lasB and rhlA. However, only the extract of Dalbergia trichocarpa bark (DTB) showed a significant reduction of QS gene expression without any effect on the aceA gene encoding a QS-independent isocitrate lyase. Further characterization of DTB impact on QS revealed that the QS systems las and rhlare inhibited and that swarming, twitching, biofilm formation and the production of pyocyanin, elastase and proteases are also hampered in the presence of the DTB extract. Importantly, compared with the known QS inhibitor naringenin, the DTB extract showed a stronger negative effect on twitching, biofilm formation and tobramycin resistance. Preliminary structural characterization of these potent biofilm disrupters suggests that they belong to the phytosterols. The strong inhibition of motility and biofilm formation suggests that the DTB extract contains agents disrupting biofilm architecture, which is an important observation in the context of the design of new drugs targeting biofilm-encapsulated pathogens. © 2013 SGM.
Authors & Co-Authors
Rasamiravaka, Tsiry
Belgium, Brussels
Université Libre de Bruxelles
Madagascar, Antananarivo
Université D'antananarivo
Jedrzejowski, Anaïs
Belgium, Brussels
Université Libre de Bruxelles
Kiendrebeogo, Martin
Belgium, Brussels
Université Libre de Bruxelles
Burkina Faso, Ouagadougou
University of Ouagadougou
Rajaonson, Sanda
Belgium, Brussels
Université Libre de Bruxelles
Madagascar, Antananarivo
Université D'antananarivo
Randriamampionona, Denis
Belgium, Brussels
Université Libre de Bruxelles
Madagascar, Antananarivo
Université D'antananarivo
Rabemanantsoa, Christian
Madagascar, Antananarivo
Institut Malgache de Recherches Appliquees Antananarivo
Andriantsimahavandy, A.
Madagascar, Antananarivo
Université D'antananarivo
Rasamindrakotroka, Andriamiliharison Jean
Madagascar, Antananarivo
Université D'antananarivo
Duez, Pierre
Belgium, Brussels
Université Libre de Bruxelles
El Jaziri, Mondher
Belgium, Brussels
Université Libre de Bruxelles
Vandeputte, Olivier M.
Belgium, Brussels
Université Libre de Bruxelles
Statistics
Citations: 44
Authors: 11
Affiliations: 4
Identifiers
Doi:
10.1099/mic.0.064378-0
ISSN:
13500872
Research Areas
Genetics And Genomics
Health System And Policy