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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences
Cell, Volume 158, No. 4, Year 2014
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Description
Acquisition of the intestinal microbiota begins at birth, and a stable microbial community develops from a succession of key organisms. Disruption of the microbiota during maturation by low-dose antibiotic exposure can alter host metabolism and adiposity. We now show that low-dose penicillin (LDP), delivered from birth, induces metabolic alterations and affects ileal expression of genes involved in immunity. LDP that is limited to early life transiently perturbs the microbiota, which is sufficient to induce sustained effects on body composition, indicating that microbiota interactions in infancy may be critical determinants of long-term host metabolic effects. In addition, LDP enhances the effect of high-fat diet induced obesity. The growth promotion phenotype is transferrable to germ-free hosts by LDP-selected microbiota, showing that the altered microbiota, not antibiotics per se, play a causal role. These studies characterize important variables in early-life microbe-host metabolic interaction and identify several taxa consistently linked with metabolic alterations. PaperClip © 2014 Elsevier Inc.
Authors & Co-Authors
Cox, Laura M.
United States, New York
Nyu Langone Health
Yamanishi, Shingo
United States, New York
Nyu Langone Health
Sohn, Jiho
United States, New York
Nyu Langone Health
Alekseyenko, Alexander V.
United States, New York
Nyu Langone Health
Leung, Jacqueline M.
United States, New York
Nyu Langone Health
Cho, Ilseung
United States, New York
Nyu Langone Health
Kim, Sungheon G.
United States, New York
Nyu Langone Health
Li, Huilin
United States, New York
Nyu Langone Health
Gao, Zhan
United States, New York
Nyu Langone Health
Mahana, Douglas
United States, New York
Nyu Langone Health
Zárate Rodriguez, Jorge G.
United Arab Emirates, Abu Dhabi
Nyu Abu Dhabi
Rogers, Arlin B.
United States, Grafton
Cummings School of Veterinary Medicine
Robine, Nicolas
United States, New York
New York Genome Center
Loke, P'Ng
United States, New York
Nyu Langone Health
Blaser, Martin J.
United States, New York
Nyu Langone Health
United States
Va Medical Center
Statistics
Citations: 1,480
Authors: 15
Affiliations: 5
Identifiers
Doi:
10.1016/j.cell.2014.05.052
ISSN:
00928674
e-ISSN:
10974172
Research Areas
Noncommunicable Diseases