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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Mefloquine treatment for uncomplicated falciparum malaria in young children 6-24 months of age in northern Ghana
American Journal of Tropical Medicine and Hygiene, Volume 76, No. 2, Year 2007
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Description
Mefloquine (MQ) single dose 20 mg/kg treatment of falciparum malaria was evaluated in 186 children of 6-24 months of age in northern Ghana. There were 15 RII/RIII-type parasitologic failures, all with Day 2 MQ blood levels significantly lower than children whose parasitemias cleared before Day 7 and remained clear through 28 days. Predictors of RII/RIII parasitologic response were vomiting after MQ dosing, Day 2 MQ levels < 500 ng/mL, and undetectable Day 2 levels of the carboxymefloquine metabolite. There were 50 cases of delayed RI parasitologic failure, but 71% of these cases had undetectable Day 28 blood levels of MQ and drug levels in the remaining 29% ranged below the 620 ng/mL level that suppresses MQ sensitive strains of P. falciparum. Drug levels among infants that tolerated MQ well were not associated with age, weight, hemoglobin, parasitemia, and pre-existing symptoms of vomiting or diarrhea. An observed recurrent parasitemia of 34,400 trophozoites/μL against a MQ blood concentration of 550 ng/mL was taken as indication of tolerance to suppressive levels of the drug at this location. Copyright © 2007 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Fryauff, David J.
United States, New York
Us Naval Medical Research Unit No. 3
Owusu-Agyei, Seth
Ghana, Navrongo
Navrongo Health Research Center
Utz, Gregory C.
United States, New York
Us Naval Medical Research Unit No. 3
Baird, John Kevin
Indonesia, Jakarta
The Asia Foundation
Koram, Kwadwo A.
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Binka, Fred Newton
Ghana, Accra
University of Ghana
Nkrumah, Francis K.
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Hoffman, Stephen L.
United States, Rockville
Sanaria Inc.
Statistics
Citations: 12
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.4269/ajtmh.2007.76.224
ISSN:
00029637
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Locations
Ghana