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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Cough aerosols of Mycobacterium tuberculosis predict new infection: A household contact study
American Journal of Respiratory and Critical Care Medicine, Volume 187, No. 9, Year 2013
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Description
Rationale: Airborne transmission of Mycobacterium tuberculosis results from incompletely characterized host, bacterial, and environmental factors. Sputum smear microscopyis associated with considerable variability in transmission. Objectives: To evaluate the use of cough-generated aerosols of M. tuberculosisto predict recent transmission. Methods: Patients with pulmonary tuberculosis (TB) underwent a standard evaluation and collection of cough aerosol cultures of M. tuberculosis. We assessed household contacts for new M. tuberculosis infection. We used multivariable logistic regression analysis with cluster adjustment to analyze predictors of new infection. Measurements and Main Results: From May 2009 to January 2011, we enrolled96 sputum culture-positive index TB cases and their 442 contacts. Only 43 (45%) patients with TB yielded M. tuberculosisin aerosols. Contacts of patients with TB who produced high aerosols (≥10 CFU) were more likely to have a new infection compared with contacts from low-aerosol (1-9 CFU) and aerosol-negative cases (69%, 25%, and 30%, respectively; P = 0.009). A high-aerosol patient withTBwas the only predictor of new M. tuber culosis infection in unadjusted (odds ratio, 5.18; 95% confidence interval, 1.52-17.61) and adjusted analyses (odds ratio, 4.81; 95% confidence interval, 1.20-19.23). Contacts of patients with TB with no aerosols versus low and high aerosols had differential tuberculin skin test and interferon-g release assay responses. Conclusions: Cough aerosols of M. tuberculosis are produced by ami-nority of patients with TB but predict transmission better than sputum smear microscopy or culture. Cough aerosols may help identify the most infectious patients with TB and thus improve the cost-effectiveness of TB control programs. Copyright © 2013 by the American Thoracic Society.
Authors & Co-Authors
Jones-López, Edward C.
United States, Boston
Boston Medical Center
Uganda, Kampala
Makerere University
United States, Newark
Rutgers new Jersey Medical School
Namugga, Olive
Uganda, Kampala
Makerere University
Mumbowa, Francis
Uganda, Kampala
Makerere University College of Health Sciences
Ssebidandi, Martin
Uganda, Kampala
Makerere University
Mbabazi, Olive
Uganda, Kampala
Makerere University College of Health Sciences
Moine, Stephanie
United States, Boston
Boston Medical Center
Mboowa, Gerald
Uganda, Kampala
Makerere University College of Health Sciences
Fox, Matthew P.
United States, Boston
School of Public Health
Reilly, Nancy
United States, Newark
Rutgers new Jersey Medical School
Ayakaka, Irene
Uganda, Kampala
Makerere University
Kim, Soyeon
United States, Newark
Rutgers new Jersey Medical School
Okwera, Alphonse
Uganda, Kampala
Makerere University
Uganda, Kampala
Mulago Hospital
Joloba, Moses Lutaakome
Uganda, Kampala
Makerere University College of Health Sciences
Fennelly, Kevin P.
Uganda, Kampala
Makerere University
United States, Gainesville
University of Florida
Statistics
Citations: 125
Authors: 14
Affiliations: 7
Identifiers
Doi:
10.1164/rccm.201208-1422OC
ISSN:
1073449X
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Case-Control Study
Study Approach
Quantitative