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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Virological and immunological factors associated with HIV-1 differential disease progression in HLA-B*58:01-positive individuals
Journal of Virology, Volume 85, No. 14, Year 2011
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Description
Molecular epidemiology studies have identified HLA-B*58:01 as a protective HIV allele. However, not all B*58:01-expressing persons exhibit slow HIV disease progression. We followed six HLA-B*58:01-positive, HIV subtype C-infected individuals for up to 31 months from the onset of infection and observed substantial variability in their clinical progression despite comparable total breadths of T cell responses. We therefore investigated additional immunological and virological factors that could explain their different disease trajectories. Cytotoxic T-lymphocyte (CTL) responses during acute infection predominantly targeted the TW10 and KF9 epitopes in p24 Gag and Nef, respectively. Failure to target the TW10 epitope in one B_58:01-positive individual was associated with low CD4 + counts and rapid disease progression. Among those targeting TW10, escape mutations arose within 2 to 15 weeks of infection. Rapid escape was associated with preexisting compensatory mutations in the transmitted viruses, which were present at a high frequency (69%) in the study population. At 1 year postinfection, B_58:01-positive individuals who targeted and developed escape mutations in the TW10 epitope (n = 5) retained significantly higher CD4 + counts (P = 0.04), but not lower viral loads, than non-B_58:01-positive individuals (n = 17). The high population-level frequency of these compensatory mutations may be limiting the protective effect of the B_58:01 allele. © 2011, American Society for Microbiology.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3126593/bin/supp_85_14_7070__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC3126593/bin/supp_85_14_7070__Chopera_et_al_Supplementary_Tables.zip
https://efashare.b-cdn.net/share/pmc/articles/PMC3126593/bin/supp_85_14_7070__Supplementary_Figure_1.zip
https://efashare.b-cdn.net/share/pmc/articles/PMC3126593/bin/supp_85_14_7070__Supplementary_Figure_1_legend.zip
Authors & Co-Authors
Chopera, Denis R.
South Africa, Cape Town
University of Cape Town
Mlotshwa, Mandla
South Africa, Johannesburg
National Institute for Communicable Diseases
Woodman, Zenda L.
South Africa, Cape Town
University of Cape Town
Mlisana, Koleka P.
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
De Assis Rosa, Debra
South Africa, Johannesburg
National Institute for Communicable Diseases
Martin, Darren Patrick
South Africa, Cape Town
University of Cape Town
Abdool Karim, Salim S.
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
Gray, Clive M.
South Africa, Johannesburg
National Institute for Communicable Diseases
Williamson, Carolyn
South Africa, Cape Town
University of Cape Town
Statistics
Citations: 32
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1128/JVI.02543-10
ISSN:
0022538X
e-ISSN:
10985514
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study