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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Hydrolyzable tannins of tamaricaceous plants. V. Structures of monomeric-trimeric tannins and cytotoxicity of macrocyclic-type tannins isolated from tamarix nilotica (1)
Journal of Natural Products, Volume 76, No. 5, Year 2013
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Description
Three new ellagitannin monomers, nilotinins M5-M7 (1-3), a dimer, nilotinin D10 (4), and a trimer, nilotinin T1 (5), together with three known dimers, hirtellin D (7) and tamarixinins B (8) and C (9), and a trimer, hirtellin T2 (6), were isolated from Tamarix nilotica dried leaves. The structures of the tannins were elucidated by intensive spectroscopic methods and chemical conversions into known tannins. The new trimer (5) is a unique macrocyclic type whose monomeric units are linked together by an isodehydrodigalloyl and two dehydrodigalloyl moieties. Additionally, dimeric and trimeric macrocyclic-type tannins isolated from T. nilotica in this study were assessed for possible cytotoxic activity against four human tumor cell lines. Tumor-selective cytotoxicities of the tested compounds were higher than those of synthetic and natural potent cytotoxic compounds, including polyphenols, and comparable with those of 5-fluorouracil and melphalan. © 2013 The American Chemical Society and American Society of Pharmacognosy.
Authors & Co-Authors
Orabi, Mohamed A.A.
Egypt, Cairo
Faculty of Pharmacy
Taniguchi, Shoko
Japan, Okayama
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Sakagami, Hiroshi
Japan, Sakado
Meikai University
Yoshimura, Morio
Japan, Matsuyama
Matsuyama University
Yoshida, Takashi
Japan, Matsuyama
Matsuyama University
Hatano, Tsutomu
Japan, Okayama
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Statistics
Citations: 25
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1021/np4001625
ISSN:
01633864
e-ISSN:
15206025
Research Areas
Cancer