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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Peripheral nerve lesions in HTLV‐I associated myelopathy (HAM/TSP)
Muscle & Nerve, Volume 16, No. 1, Year 1993
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Description
Peripheral nerve dysfunction (PND) was found in as many as 43% of our patients with human T‐cell lymphotropic virus type I (HTLV‐I)–associated myelopathy (HAM/TSP). To evaluate the PND further we biopsied the sural nerve in 6 patients. The histological features were varying degrees of demyelination, remyelination, axonal atrophy and degeneration, and perineurial fibrosis. “Globule” or “sausage” formation was prominent in two of the specimens. Inflammatory infiltrates were absent. No deposits of IgG, IgM, IgA, or complement were detected in the biopsies. No viral antigen or proviral DNA was detected. It is proposed that the PND and the histological findings noted are part of HTLV‐I–associated disease and not an unrelated disorder. The pathogenesis of the PND remains unclear. There was no evidence of direct viral infection. The histological findings could represent primary changes induced by viral‐triggered release of soluble factors, such as cytokines or secondary changes to more proximal disease, e.g., root involvement. © 1993 John Wiley & Sons, Inc. Copyright © 1993 John Wiley & Sons, Inc.
Authors & Co-Authors
Bhigjee, Ahmed Iqbal G.
South Africa, Congella
University of Natal, Faculty of Medicine
Bill, Pierre Louise Alfred
South Africa, Congella
University of Natal, Faculty of Medicine
Wiley, Clayton A.
United States, La Jolla
University of California, San Diego
Windsor, Isobel M.
South Africa, Congella
University of Natal, Faculty of Medicine
Matthias, Denise A.
South Africa, Congella
University of Natal, Faculty of Medicine
Amenomori, Tatsuhiko
United States, La Jolla
University of California, San Diego
Wachsman, William
United States, La Jolla
University of California, San Diego
United States, San Diego
Research Service
Moorhouse, David
United States, La Jolla
University of California, San Diego
Statistics
Citations: 8
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1002/mus.880160106
ISSN:
0148639X
e-ISSN:
10974598
Research Areas
Genetics And Genomics