Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Consecutive determinations of seroreactivities to Pf 155/RESA antigen and to its different repetitive sequences in adult men from a holoendemic area of Liberia
Parasite Immunology, Volume 12, No. 2, Year 1990
Notification
URL copied to clipboard!
Description
Summary Sera from 32 adult men residing in a malaria holoendemic area of Liberia were investigated for seroreactivities to different asexual blood‐stage malaria antigens on five consecutive occasions from 1984 to 1986. The seroreactivities to crude parasitic antigens and to Pf 155/RESA (EMIF) were determined by immunofluorescence and to repetitive sequences of Pf 155/RESA by enzyme‐linked immunosorbent assay (ELISA). All sera were highly reactive against the crude parasitic antigens with reciprocal titres varying from 5000 to 100000. The EMIF titres showed a wider variation from negative (< 10) to 25000, and when the same individuals were re‐examined on subsequent surveys similar EMIF titres were found. The ELISA seroreactivities to three different repetitive sequences of Pf 155/RESA also showed different individual profiles which were rather consistent on consecutive surveys. High EMIF titres appeared to be correlated mainly to one of the peptide sequences, namely (EENV)2. The consistent individual profiles of the seroreactivities to Pf 155 and its repetitive sequences suggest genetic restriction of the humoral immune response. Although no significant correlation was found between EMIF titres and parasitic densities in the adult hyperimmune men the specific peptides, however, offer new possibilities of further investigating protective capacities of different immune responses to specific epitopes of the malaria parasite. Copyright © 1990, Wiley Blackwell. All rights reserved
Authors & Co-Authors
Bjǒrkman, Anders B.
Liberia
Liberian Institute of Biomedical Research
Perlmann, Hedvig K.
Sweden, Stockholm
Stockholms Universitet
Petersen, Eskild
Liberia
Liberian Institute of Biomedical Research
Sweden, Stockholm
Karolinska Institutet
Högh, Birthe
Liberia
Liberian Institute of Biomedical Research
Sweden, Stockholm
Stockholms Universitet
Lebbad, Marianne
Sweden, Stockholm
National Bacteriological Laboratory Stockholm
Warsame, Marian Yusuf
Sweden, Stockholm
National Bacteriological Laboratory Stockholm
Hanson, A. P.
Liberia
Liberian Institute of Biomedical Research
Perlmann, Peter H.
Sweden, Stockholm
Stockholms Universitet
Statistics
Citations: 24
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1111/j.1365-3024.1990.tb00941.x
ISSN:
01419838
e-ISSN:
13653024
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Liberia
Participants Gender
Male