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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Highly pathogenic avian influenza virus H5N1 from Egypt escapes vaccine-induced immunity but confers clinical protection against a heterologous clade 2.2.1 Egyptian isolate
Vaccine, Volume 29, No. 33, Year 2011
Notification
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Description
The poultry populations of Egypt are endemically infected by highly pathogenic avian influenza viruses (HPAIV) of subtype H5N1. Vaccination was chosen as an auxiliary tool to control HPAIV in poultry. Potency of commercial vaccines regarding emerging variants is under discussion. In the current study efficacy of four different inactivated whole H5 virus vaccines representing different sublineages of HPAIV H5N1 were tested in chickens against challenge viruses currently co-circulating in Egypt and representing two antigenically widely distinct HPAIV H5N1 lineages, i.e., "variant" (clade 2.2.1var) and "proper" (clade 2.2.1pro) viruses. All vaccines induced clinical protection against challenge with 2.2.1pro Egyptian strains. In contrast, when challenged with a variant strain, only chickens vaccinated with the homologous Egyptian clade 2.2.1var virus or an inactivated re-assorted H5N1 strain (Re-5, clade 2.3) were protected. However, only the homologous virus induced sterile immunity whereas chickens clinically protected after Re-5 vaccination shed virus at day two after infection indistinguishable to H5N2 vaccines. In conclusion, monitoring vaccine-driven evolution of HPAIV H5N1 by surveillance, antigenic characterization, and challenge studies is essential to assess efficacy of AIV vaccination campaigns. © 2011 Elsevier Ltd.
Authors & Co-Authors
Grund, Christian H.
Germany, Tubingen
Friedrich-loeffler-institute
Abdelwhab, Elsayed M.
Germany, Tubingen
Friedrich-loeffler-institute
Germany, Berlin
Freie Universität Berlin
Egypt, Giza
Central Laboratory for Quality Control of Poultry Productionclqp
Arafa, Abdel Satar A.
Egypt, Giza
Central Laboratory for Quality Control of Poultry Productionclqp
Ziller, Mario
Germany, Tubingen
Friedrich-loeffler-institute
Hassan, Mohammed Ismail
Egypt, Giza
Central Laboratory for Quality Control of Poultry Productionclqp
Aly, Mona Meherez
Egypt, Giza
Central Laboratory for Quality Control of Poultry Productionclqp
Hafez, Hafez Mohamed
Germany, Berlin
Freie Universität Berlin
Harder, Timm Clemens
Germany, Tubingen
Friedrich-loeffler-institute
Beer, Martin
Germany, Tubingen
Friedrich-loeffler-institute
Statistics
Citations: 101
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1016/j.vaccine.2011.01.006
ISSN:
0264410X
e-ISSN:
18732518
Study Locations
Egypt