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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Antimicrobial drug resistance of Salmonella enterica serovar Typhi in Asia and molecular mechanism of reduced susceptibility to the fluoroquinolones
Antimicrobial Agents and Chemotherapy, Volume 51, No. 12, Year 2007
Notification
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Description
This study describes the pattern and extent of drug resistance in 1,774 strains of Salmonella enterica serovar Typhi isolated across Asia between 1993 and 2005 and characterizes the molecular mechanisms underlying the reduced susceptibilities to fluoroquinolones of these strains. For 1,393 serovar Typhi strains collected in southern Vietnam, the proportion of multidrug resistance has remained high since 1993 (50% in 2004) and there was a dramatic increase in nalidixic acid resistance between 1993 (4%) and 2005 (97%). In a cross-sectional sample of 381 serovar Typhi strains from 8 Asian countries, Bangladesh, China, India, Indonesia, Laos, Nepal, Pakistan, and central Vietnam, collected in 2002 to 2004, various rates of multidrug resistance (16 to 37%) and nalidixic acid resistance (5 to 51%) were found. The eight Asian countries involved in this study are home to approximately 80% of the world's typhoid fever cases. These results document the scale of drug resistance across Asia. The Ser83→Phe substitution in GyrA was the predominant alteration in serovar Typhi strains from Vietnam (117/127 isolates; 92.1%). No mutations in gyrB, parC, or parE were detected in 55 of these strains. In vitro time-kill experiments showed a reduction in the efficacy of ofloxacin against strains harboring a single-amino-acid substitution at codon 83 or 87 of GyrA; this effect was more marked against a strain with a double substitution. The 8-methoxy fluoroquinolone gatifloxacin showed rapid killing of serovar Typhi harboring both the single- and double-amino-acid substitutions. Copyright © 2007, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Chau, Tran Thuy
Unknown Affiliation
Campbell, James Ian
Unknown Affiliation
Galindo, Claudia M.
Unknown Affiliation
van Minh Hoang, Nguyen Van Minh
Unknown Affiliation
To, Song Diep
Unknown Affiliation
Nga, Tran Vu Thieu
Unknown Affiliation
Chau, Nguyen Van Vinh
Unknown Affiliation
Phung, Quoc Tuan
Unknown Affiliation
Page, Anne Laure
Unknown Affiliation
Ochiai, R. Leon
Unknown Affiliation
Schultsz, Constance
Unknown Affiliation
Wain, John R.
Unknown Affiliation
Bhutta, Zulfiqar A.
Unknown Affiliation
Parry, Christopher Mark
Unknown Affiliation
Bhattacharya, Sujit Kumar
Unknown Affiliation
Dutta, Dr Shanta
Unknown Affiliation
Agtini, Magdarina Destri
Unknown Affiliation
Dong, Baiqing
Unknown Affiliation
Honghui, Yang
Unknown Affiliation
Anh, Dang Duc
Unknown Affiliation
Do, Gia Canh
Unknown Affiliation
Naheed, Aliya
Unknown Affiliation
Albert, Manuel John
Unknown Affiliation
Phetsouvanh, Rattanaphone
Unknown Affiliation
Newton, Paul N.
Unknown Affiliation
Basnyat, Buddha
Unknown Affiliation
Arjyal, Amit
Unknown Affiliation
La, Tran Thi Phi
Unknown Affiliation
Nguyen, Ngoc Rang
Unknown Affiliation
Le, Thi Phuong
Unknown Affiliation
Bay, Phan Van Be
Unknown Affiliation
Von-Seidlein, Lorenz
Unknown Affiliation
Dougan, Gordon J.
Unknown Affiliation
Clemens, John David
Unknown Affiliation
Vinh, Ha
Unknown Affiliation
Tran, Tinh Hien
Unknown Affiliation
Nguyen, Tran Chinh
Unknown Affiliation
Acosta, Camilo J.
Unknown Affiliation
Farrar, Jeremy James
Unknown Affiliation
Dolecek, Christiane
Unknown Affiliation
Statistics
Citations: 243
Authors: 40
Affiliations: 19
Identifiers
Doi:
10.1128/AAC.00294-07
ISSN:
00664804
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study