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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals
Nature Genetics, Volume 52, No. 12, Year 2020
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Description
Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency > 0.05). In a meta-analysis of up to ~1.3 million participants, we discovered 106 new BP-associated genomic regions and 87 rare (minor allele frequency ≤ 0.01) variant BP associations (P < 5 × 10−8), of which 32 were in new BP-associated loci and 55 were independent BP-associated single-nucleotide variants within known BP-associated regions. Average effects of rare variants (44% coding) were ~8 times larger than common variant effects and indicate potential candidate causal genes at new and known loci (for example, GATA5 and PLCB3). BP-associated variants (including rare and common) were enriched in regions of active chromatin in fetal tissues, potentially linking fetal development with BP regulation in later life. Multivariable Mendelian randomization suggested possible inverse effects of elevated systolic and diastolic BP on large artery stroke. Our study demonstrates the utility of rare-variant analyses for identifying candidate genes and the results highlight potential therapeutic targets. © 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.
Authors & Co-Authors
Surendran, Praveen
United Kingdom, London
British Heart Foundation
United Kingdom, London
Health Data Research uk
United Kingdom, Cambridge
University of Cambridge
Feofanova, Elena Valeryevna
United States, Houston
University of Texas Health Science Center at Houston
Lahrouchi, Najim
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Massachusetts General Hospital
Netherlands, Amsterdam
Amsterdam Cardiovascular Sciences
Ntalla, Ioanna
United Kingdom, London
Queen Mary University of London
Karthikeyan, Savita
United Kingdom, London
British Heart Foundation
Cook, James P.
United Kingdom, Liverpool
University of Liverpool
Yao, Chen
United States, Framingham
Framingham Heart Study
United States, Bethesda
National Institutes of Health Nih
Kraja, Aldi T.
United States, St. Louis
Washington University School of Medicine in St. Louis
Hellwege, Jacklyn N.
United States, Nashville
Vanderbilt University
Tragante, Vinicius
Netherlands, Utrecht
Universiteit Utrecht
Iceland, Reykjavik
Decode Genetics
Thorleifsson, Gudmar
Iceland, Reykjavik
Decode Genetics
Liu, Dajiang J.
United States, Hershey
Penn State College of Medicine
Prins, Bram Peter
United Kingdom, London
British Heart Foundation
Stewart, Isobel D.
United Kingdom, Cambridge
School of Clinical Medicine
Cabrera, Claudia P.
United Kingdom, London
Queen Mary University of London
United Kingdom, Royston
National Institute for Health and Care Research
Eales, James M.
United Kingdom, Manchester
The University of Manchester
Auer, Paul Livermore
United States, Milwaukee
University of Wisconsin-milwaukee
Bielak, Lawrence F.
United States, Ann Arbor
University of Michigan, Ann Arbor
Bis, Joshua C.M.
United States, Seattle
University of Washington
Braithwaite, V. S.
United Kingdom, Cambridge
School of Clinical Medicine
United Kingdom, London
Medical Research Council
Gambia, Banjul
Medical Research Council Laboratories Gambia
Brody, Jennifer A.
United States, Seattle
University of Washington
Daw, E. Warwick
United States, St. Louis
Washington University School of Medicine in St. Louis
Warren, Helen R.
United Kingdom, London
Queen Mary University of London
United Kingdom, Royston
National Institute for Health and Care Research
Drenos, Fotios
United Kingdom, Uxbridge
Brunel University London
United Kingdom, London
University College London
Nielsen, Sune Fallgaard
Denmark, Copenhagen
Copenhagen University Hospital
Faul, Jessica D.
United States, Ann Arbor
University of Michigan, Ann Arbor
Fauman, Eric B.
United States, New York
Pfizer Inc.
Fava, Cristiano
Italy, Verona
Università Degli Studi Di Verona
Sweden, Lund
Lunds Universitet
Ferreira, Teresa
United Kingdom, Oxford
University of Oxford
Franceschini, Nora
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Gao, He
United Kingdom, London
Imperial College London
Giannakopoulou, Olga
United Kingdom, London
Queen Mary University of London
United Kingdom, London
University College London
Giulianini, Franco
United States, Boston
Brigham and Women's Hospital
Gudbjartsson, Daníel Fannar
Iceland, Reykjavik
Decode Genetics
Iceland, Reykjavik
Haskoli Islands
Guo, Xiuqing
United States, Torrance
The Lundquist Institute
Harris, Sarah E.
United Kingdom, Edinburgh
The University of Edinburgh
Havulinna, Aki Samuli
United Kingdom, Edinburgh
The University of Edinburgh
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Helgadóttir, Anna
Iceland, Reykjavik
Decode Genetics
Huffman, Jennifer E.
United Kingdom, Edinburgh
Western General Hospital
Hwang, Shihjen
United States, Bethesda
National Institutes of Health Nih
United States, Boston
Boston University
Kanoni, Stavroula
United Kingdom, London
Queen Mary University of London
Kontto, Jukka P.
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Li-Gao, Ruifang
Netherlands, Leiden
Leids Universitair Medisch Centrum
Lindstr̈om, Jaana
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Lotta, Luca Andrea
United Kingdom, Cambridge
School of Clinical Medicine
Lu, Yingchang
United States, New York
Icahn School of Medicine at Mount Sinai
United States, Nashville
Vanderbilt University School of Medicine
Luan, Jian'fan N.An
United Kingdom, Cambridge
School of Clinical Medicine
Mahajan, Anubha
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
United Kingdom, Oxford
University of Oxford
Malerba, Giovanni A.
Italy, Verona
Università Degli Studi Di Verona
Masca, Nicholas G.D.
United Kingdom, Leicester
University of Leicester
Mei, Hao
United States, Jackson
University of Mississippi Medical Center
Menni, Cristina
United Kingdom, London
King's College London
Mook-Kanamori, Dennis Owen
Netherlands, Leiden
Leids Universitair Medisch Centrum
Müller-Nurasyid, Martina
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Germany, Munich
Ludwig-maximilians-universität München
Paré, Guillaume
Canada, Hamilton
Mcmaster University
Paul, Dirk S.
United Kingdom, London
British Heart Foundation
United Kingdom, Royston
National Institute for Health and Care Research
Perola, Markus
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Finland, Helsinki
Helsingin Yliopisto
Poveda, Alaitz
Sweden, Lund
Skånes Universitetssjukhus
Rauramaa, Rainer
Finland, Kuopio
Itä-suomen Yliopisto
Finland, Kuopio
Kuopio University Hospital
Richard, Melissa A.
United States, Houston
University of Texas Health Science Center at Houston
Richardson, Tom G.
United Kingdom, Bristol
University of Bristol
Sepúlveda, Nuno
United Kingdom, London
London School of Hygiene & Tropical Medicine
Portugal, Lisbon
Universidade de Lisboa
Sim, Xueling
United States, Ann Arbor
University of Michigan, Ann Arbor
Singapore, Singapore City
National University of Singapore
Smith, Albert Vernon
Iceland, Kopavogur
Icelandic Heart Association
Iceland, Reykjavik
Haskoli Islands
United States, Ann Arbor
University of Michigan, Ann Arbor
Smith, Jennifer Anne
United States, Ann Arbor
University of Michigan, Ann Arbor
Sulem, Patrick
Iceland, Reykjavik
Decode Genetics
Thériault, Sébastien S.
Canada, Hamilton
Mcmaster University
Canada, Quebec
Université Laval
Thorsteinsdóttir, Unnur Arna
Iceland, Reykjavik
Decode Genetics
Iceland, Reykjavik
Haskoli Islands
Trompet, Stella
Netherlands, Leiden
Leids Universitair Medisch Centrum
Varga, Tibor V.
Sweden, Lund
Skånes Universitetssjukhus
Velez-Edwards, Digna R.
United States, Nashville
Vanderbilt University Medical Center
Veronesi, Giovanni
Italy, Varese
Università Degli Studi Dell'insubria
Weiss, Stefan
Germany, Greifswald
Universität Greifswald
Germany, Berlin
Deutsches Zentrum Für Herz-kreislauf-forschung E. V.
Willems, Sara M.
United Kingdom, Cambridge
School of Clinical Medicine
Yao, Jie
United States, Torrance
The Lundquist Institute
Young, Robin D.
United Kingdom, London
British Heart Foundation
United Kingdom, Glasgow
University of Glasgow
Yu, Bing
United States, Houston
University of Texas Health Science Center at Houston
Zhang, Weihua
United Kingdom, London
Imperial College London
United Kingdom, Southall
Ealing Hospital
Zhao, Jinghua
United Kingdom, London
British Heart Foundation
United Kingdom, Cambridge
School of Clinical Medicine
United Kingdom, Royston
National Institute for Health and Care Research
Zhao, Wei
United States, Philadelphia
University of Pennsylvania
Zhao, Wei
United States, Ann Arbor
University of Michigan, Ann Arbor
Evangelou, Evangelos
United Kingdom, London
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Greece, Ioannina
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Aeschbacher, Stefanie
Switzerland, Basel
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Blankenberg, Stefan S.
Germany, Berlin
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Germany, Hamburg
Universitäre Herz- Und Gefäßzentrum Uke Hamburg Gmbh
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Bonnycastle, Lori L.C.
United States, Bethesda
National Institutes of Health Nih
Bork-Jensen, Jette
Denmark, Copenhagen
Københavns Universitet
Brandslund, Ivan
Denmark, Vejle
Sygehus Lillebælt - Vejle
Denmark, Odense
Syddansk Universitet
Braund, Peter S.
United Kingdom, Leicester
University of Leicester
Burgess, Stephen
United Kingdom, London
British Heart Foundation
United Kingdom, Cambridge
University of Cambridge
United Kingdom, Royston
National Institute for Health and Care Research
Cho, Kelly
United States, West Roxbury
Va Boston Healthcare System
United States, Boston
Brigham and Women's Hospital
United States, Boston
Harvard Medical School
Christensen, Cramer Kjeldahl
Denmark, Vejle
Sygehus Lillebælt - Vejle
Connell, John M.C.
United Kingdom, Dundee
University of Dundee
Mutsert, Renée De
Netherlands, Leiden
Leids Universitair Medisch Centrum
Dominiczak, Anna F.D.
United Kingdom, Glasgow
College of Medical, Veterinary & Life Sciences
Dörr, Marcus
Germany, Berlin
Deutsches Zentrum Für Herz-kreislauf-forschung E. V.
Germany, Greifswald
Universitätsmedizin Greifswald
Eiríksdóttir, Gudný H.
Iceland, Kopavogur
Icelandic Heart Association
Gaziano, John Michael
United States, West Roxbury
Va Boston Healthcare System
United States, Boston
Brigham and Women's Hospital
United States, Boston
Harvard Medical School
Grarup, Niels
Denmark, Copenhagen
Københavns Universitet
Grove, Megan L.
United States, Houston
University of Texas Health Science Center at Houston
Hallmans, Goran
Sweden, Umea
Umeå Universitet
Hansen, Torben
Denmark, Copenhagen
Københavns Universitet
Theil Have, Christian
Denmark, Copenhagen
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Heiss, Gerardo M.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Jørgensen, Marit E. Eika
Denmark, Herlev
Steno Diabetes Center Copenhagen
Jousilahti, Pekka J.
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Kajantie, Eero O.
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Finland, Oulu
Oulun Yliopisto
Norway, Trondheim
Norges Teknisk-naturvitenskapelige Universitet
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Käräjämäki, Annemari Mari
Finland, Vaasa
Vasa Central Sjukhus
Karpe, Fredrik
United Kingdom, Oxford
University of Oxford
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Koistinen, Heikki A.
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Finland, Helsinki
Helsingin Yliopisto
Finland, Helsinki
Minerva Foundation Institute for Medical Research Helsinki
Kovesdy, Csaba P.
United States, Memphis
Memphis va Medical Center
Kuulasmaa, Kari A.
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Laatikainen, Tiina Km
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Finland, Kuopio
Kuopio University Hospital
Lannfelt, Lars L.
Sweden, Uppsala
Uppsala Universitet
Lee, Ii Te
Taiwan, Taichung
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Taiwan, Taipei
National Yang-ming University Taiwan
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Taiwan, Taichung
Tunghai University
Lee, Wen Jane
Taiwan, Taichung
Veterans General Hospital-taichung Taiwan
Taiwan, Taichung
Tunghai University
De Boer, Rudolf A.
Netherlands, Groningen
Rijksuniversiteit Groningen
van der Harst, Pim
Netherlands, Groningen
Rijksuniversiteit Groningen
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Netherlands Heart Institute
van der Meer, Peter
Netherlands, Groningen
Rijksuniversiteit Groningen
Linneberg, Allan R.
Denmark, Copenhagen
Frederiksberg Hospital
Denmark, Copenhagen
Københavns Universitet
Martin, Lisa Warsinger
United States, Washington, D.c.
The George Washington University School of Medicine and Health Sciences
Nadkarni, Girish N.
United States, New York
Icahn School of Medicine at Mount Sinai
Neville, Matt J.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
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Palmer, Colin Neil Alexander
United Kingdom, Dundee
University of Dundee
Papanicolaou, George John
United States, Bethesda
National Heart, Lung, and Blood Institute Nhlbi
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Denmark, Copenhagen
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Peters, James E.
United Kingdom, London
British Heart Foundation
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United Kingdom, London
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Pakistan, Karachi
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Rayner, Nigel William
United Kingdom, Oxford
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University of Oxford
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Estonia, Tartu
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Renström, Frida
Sweden, Lund
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Rettig, Rainer
Germany, Berlin
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Rossouw, Jacques E.
United States, Bethesda
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Schreiner, Pamela J.
United States, Minneapolis
University of Minnesota Twin Cities
Sever, Peter S.
United Kingdom, London
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Skaaby, Tea
Denmark, Copenhagen
Frederiksberg Hospital
Sun, Yan V.
United States, Atlanta
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Iceland, Reykjavik
Decode Genetics
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Università Degli Studi Di Verona
Tsao, Phillip Shih Chung
United States, Palo Alto
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Tuomi, Tiinamaija
Finland, Helsinki
Folkhälsan
Finland, Helsinki
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Finland, Helsinki
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Tzoulaki, Ioanna
United Kingdom, London
Imperial College London
Greece, Ioannina
Faculty of Medicine
Vaartjes, Ilonca C.H.
Netherlands, Utrecht
Universiteit Utrecht
Vergnaud, Anne Claire
United Kingdom, London
Imperial College London
Willer, Cristen J.
United States, Ann Arbor
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Wilson, Peter W.F.
United States, Decatur
Atlanta va Medical Center
Witte, Daniel R.
Denmark, Aarhus
Aarhus Universitet
Denmark, Herlev
Steno Diabetes Center Copenhagen
Yonova-Doing, Ekaterina
United Kingdom, London
British Heart Foundation
Zhang, He
United States, Ann Arbor
University of Michigan, Ann Arbor
Almgren, Peter
Sweden, Lund
Lunds Universitet
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France, Lille
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Chu Lille
France, Lille
Institut Pasteur de Lille
Asselbergs, Folkert W.
Netherlands, Utrecht
Universiteit Utrecht
United Kingdom, London
University College London
United Kingdom, London
Health Data Research uk
Blakemore, Alexandra I.F.
United Kingdom, Uxbridge
Brunel University London
United Kingdom, London
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Boehnke, Michael L.
United States, Ann Arbor
University of Michigan, Ann Arbor
Bots, Michiel L.
Netherlands, Utrecht
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Böttinger, Erwin P.
United States, New York
Icahn School of Medicine at Mount Sinai
Buring, Julie E.
United States, Boston
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United States, Boston
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Chambers, John Campbell
United Kingdom, London
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United Kingdom, Southall
Ealing Hospital
Singapore, Singapore City
Nanyang Technological University
United Kingdom, London
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Chen, Yii Der Ida
United States, Torrance
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Chowdhury, Rajiv H.
United Kingdom, London
British Heart Foundation
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Conen, David
Canada, Hamilton
Mcmaster University
Switzerland, Basel
Cardiovascular Research Institute Basel
Correa, Adolfo
Unknown Affiliation
Davey-Smith, George
United Kingdom, Bristol
University of Bristol
Deary, Ian J.
United Kingdom, Edinburgh
The University of Edinburgh
Dedoussis, George V.Z.
Greece, Athens
Harokopio University of Athens
Deloukas, Panos
United Kingdom, London
Queen Mary University of London
United Kingdom, Royston
National Institute for Health and Care Research
Saudi Arabia, Jeddah
King Abdulaziz University
Di Angelantonio, Emanuele
United Kingdom, London
British Heart Foundation
United Kingdom, London
Health Data Research uk
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Elliott, Paul E.
United Kingdom, London
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Butterworth, Adam S.
United Kingdom, London
British Heart Foundation
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Health Data Research uk
United Kingdom, Royston
National Institute for Health and Care Research
United Kingdom, Cambridge
University of Cambridge
Danesh, John N.
United Kingdom, London
British Heart Foundation
United Kingdom, London
Health Data Research uk
United Kingdom, Royston
National Institute for Health and Care Research
United Kingdom, Cambridge
University of Cambridge
United Kingdom, Hinxton
Wellcome Sanger Institute
Langenberg, Claudia C.
United Kingdom, Cambridge
School of Clinical Medicine
Franks, Paul W.
Sweden, Lund
Skånes Universitetssjukhus
United States, Boston
Harvard T.h. Chan School of Public Health
Sweden, Umea
Umeå Universitet
United Kingdom, Oxford
University of Oxford
Rolandsson, Olov
Sweden, Umea
Umeå Universitet
Wareham, Nicholas J.
United Kingdom, Cambridge
School of Clinical Medicine
Felix, Stephan Burkhard
Germany, Berlin
Deutsches Zentrum Für Herz-kreislauf-forschung E. V.
Germany, Greifswald
Universitätsmedizin Greifswald
Ferriéres, Jean
France, Paris
Inserm
Ford, Ian
United Kingdom, Glasgow
University of Glasgow
Fornage, Myriam
United States, Houston
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Franks, Stephen
United Kingdom, London
Imperial College London
Frossard, Philippe M.
Pakistan, Karachi
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Gambaro, Giovanni
Italy, Verona
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Gaunt, Tom R.
United Kingdom, Bristol
University of Bristol
Groop, Leif C.
Sweden, Malmo
Lund University Diabetes Centre
Finland, Helsinki
Helsingin Yliopisto
Gudnason, V. G.
Iceland, Kopavogur
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Iceland, Reykjavik
Haskoli Islands
Harris, Tamara B.
United States, Bethesda
National Institute on Aging Nia
Hayward, Caroline
United Kingdom, Edinburgh
Western General Hospital
Hennig, Branwen J.W.
Gambia, Banjul
Medical Research Council Laboratories Gambia
United Kingdom, London
Wellcome Trust
Herzig, Karl-Heinz
Finland, Oulu
Oulu University Hospital
Poland, Poznan
Poznan University of Medical Sciences
Ingelsson, Erik
United States, Stanford
Stanford University School of Medicine
Sweden, Solna
Science for Life Laboratory
United States, Palo Alto
Stanford University
Tuomilehto, Jaakko O.I.
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Finland, Helsinki
Helsingin Yliopisto
Saudi Arabia, Jeddah
King Abdulaziz University
J̈arvelin, Märjo Riitta R.
United Kingdom, Uxbridge
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United Kingdom, London
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Finland, Oulu
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Jukema, Johan Wouter
Netherlands, Leiden
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Kardia, Sharon L.R.
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Kee, Frank
United Kingdom, Belfast
Queen's University Belfast
Kooner, Jaspal Singh
United Kingdom, London
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United Kingdom, London
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United States, Seattle
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Launer, Lenore J.
United States, Bethesda
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Lind, Lars L.
Sweden, Uppsala
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Loos, Ruth J.F.
United States, New York
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Laakso, M. M.
Finland, Kuopio
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United Kingdom, Oxford
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Melander, Olle
Sweden, Lund
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Mohlke, Karen
United States, Chapel Hill
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Denmark, Copenhagen
Copenhagen University Hospital
Orho-Melander, Marju
Sweden, Lund
Lunds Universitet
Packard, Christopher J.D.
United Kingdom, Glasgow
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United Kingdom, Glasgow
University of Glasgow
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United States, New York
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Polašek, Ozren
Croatia, Split
School of Medicine, University of Split
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United Kingdom, Edinburgh
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United Kingdom, Edinburgh
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Gambia, Banjul
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Province, Michael A.
United States, St. Louis
Washington University School of Medicine in St. Louis
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United Kingdom, Bristol
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Netherlands, Leiden
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United Kingdom, Edinburgh
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Finland, Helsinki
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Samani, Nilesh J.
United Kingdom, Leicester
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United Kingdom, Glasgow
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Sheu, Wayne Huey Herng
Taiwan, Taichung
Veterans General Hospital-taichung Taiwan
Taiwan, Taipei
National Yang-ming University Taiwan
Taiwan, Taipei
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Taiwan, Taichung
National Chung Hsing University
Smith, Blair H.
United Kingdom, Dundee
University of Dundee
Spector, Tim David
United Kingdom, London
King's College London
Starr, John Michael
United Kingdom, Edinburgh
The University of Edinburgh
Sébert, Sylvain P.
Finland, Oulu
Oulun Yliopisto
Taylor, Kent D.
United States, Torrance
The Lundquist Institute
Lakka, Timo Antero
Finland, Kuopio
Itä-suomen Yliopisto
Finland, Kuopio
Kuopio University Hospital
Timpson, Nicholas J.
United Kingdom, Bristol
University of Bristol
Tobin, Martin D.
United Kingdom, Leicester
University of Leicester
Zeggini, Eleftheria
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Germany, Munich
Technische Universität München
Australia, Ballarat
Federation University Australia
Ramachandran, Vasan S.
United States, Boston
Boston University
Virtamo, Jarmo R.K.
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Völker, Uwe
Germany, Greifswald
Universität Greifswald
Germany, Berlin
Deutsches Zentrum Für Herz-kreislauf-forschung E. V.
Weir, David R.
United States, Ann Arbor
University of Michigan, Ann Arbor
Zeggini, Eleftheria
United Kingdom, Hinxton
Wellcome Sanger Institute
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Germany, Munich
Technische Universität München
Charchar, Fadi J.
United Kingdom, Leicester
University of Leicester
Australia, Ballarat
Federation University Australia
Australia, Melbourne
University of Melbourne
Giri, Ayush
United States, Nashville
Vanderbilt University
Cho, Kelly M.
United States, West Roxbury
Va Boston Healthcare System
United States, Boston
Brigham and Women's Hospital
United States, Boston
Harvard Medical School
Sun, Yan V.
United States, Atlanta
Emory University
Edwards, Todd L.
United States, Nashville
Vanderbilt University
Hung, Adrianna M.
United States
Va Medical Center
O′Donnell, Christopher J.
United States, Boston
Brigham and Women's Hospital
Tomaszewski, Maciej
United Kingdom, Manchester
The University of Manchester
United Kingdom, Manchester
Manchester University Nhs Foundation Trust
Caulfield, Mark J.
United Kingdom, London
Queen Mary University of London
United Kingdom, Royston
National Institute for Health and Care Research
Danesh, John N.
United Kingdom, London
British Heart Foundation
United Kingdom, London
Health Data Research uk
United Kingdom, Royston
National Institute for Health and Care Research
United Kingdom, Cambridge
University of Cambridge
United Kingdom, Hinxton
Wellcome Sanger Institute
Hólm, Hilma
Iceland, Reykjavik
Decode Genetics
Lindgren, Cecilia M.
United States, Cambridge
Massachusetts Institute of Technology
United Kingdom, Oxford
University of Oxford
Liu, Chunyu
United States, Boston
School of Public Health
Manning, Alisa Knodle
United States, Boston
Harvard Medical School
United States, Boston
Massachusetts General Hospital
Morris, Andrew Paul
United Kingdom, Liverpool
University of Liverpool
United Kingdom, Oxford
University of Oxford
United Kingdom, Manchester
The University of Manchester
Morrison, Alanna C.
United States, Houston
University of Texas Health Science Center at Houston
Psaty, Bruce M.
United States, Seattle
University of Washington
United States, Washington, D.c.
United States Department of Health and Human Services
United States, Oakland
Kaiser Permanente
Saleheen, Danish
United Kingdom, London
British Heart Foundation
United States, Philadelphia
University of Pennsylvania
Pakistan, Karachi
Center for Non-communicable Diseases
Stefánsson, Kari
Iceland, Reykjavik
Decode Genetics
Iceland, Reykjavik
Haskoli Islands
Boerwinkle, Eric A.
United States, Houston
University of Texas Health Science Center at Houston
United States, Houston
Baylor College of Medicine
Chasman, Daniel I.
United States, Boston
Brigham and Women's Hospital
United States, Boston
Harvard Medical School
Levy, Daniel A.
United States, Boston
Boston University
United States, Bethesda
National Institutes of Health Nih
Newton-Cheh, Christopher H.
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Massachusetts General Hospital
Munroe, Patricia B.
United Kingdom, London
Queen Mary University of London
United Kingdom, Royston
National Institute for Health and Care Research
Howson, Joanna M.M.
United Kingdom, London
British Heart Foundation
United Kingdom, Royston
National Institute for Health and Care Research
United Kingdom, Oxford
University of Oxford
Statistics
Citations: 64
Authors: 263
Affiliations: 152
Identifiers
Doi:
10.1038/s41588-020-00713-x
ISSN:
10614036
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Study Design
Randomised Control Trial
Study Approach
Systematic review