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Accelerated Immunodeficiency-associated Vaccine-derived Poliovirus Serotype 3 Sequence Evolution Rate in an 11-week-old Boy with X-linked Agammaglobulinemia and Perinatal Human Immunodeficiency Virus Exposure

Clinical Infectious Diseases, Volume 70, No. 1, Year 2020

Primary B-cell immunodeficiencies are risk factors for the generation of vaccine-derived polioviruses. We report immunodeficiency-associated vaccine-derived poliovirus serotype 3 in an 11-week-old boy with X-linked agammaglobulinemia. Unique characteristics of this case include early age of presentation, high viral evolutionary rate, and the child's perinatal exposure to human immunodeficiency virus.

Jallow, Sabelle
1. South Africa, Johannesburg National Institute for Communicable Diseases
Wilmshurst, J. Madeleine
1. South Africa, Cape Town University of Cape Town
Howard, Wayne
1. South Africa, Johannesburg National Institute for Communicable Diseases
Copelyn, J.
1. South Africa, Cape Town University of Cape Town
Seakamela, Lerato
1. South Africa, Johannesburg National Institute for Communicable Diseases
Chan, Koonwing
1. Hong Kong, Hong Kong The University of Hong Kong
Sebunya, Robert
1. South Africa, Cape Town University of Cape Town
Sibiya, Rosina
1. South Africa, Johannesburg National Institute for Communicable Diseases
du Plessis, Heleen
1. South Africa, Johannesburg National Institute for Communicable Diseases
Jacobs, Charlene Ann
1. South Africa, Cape Town Western Cape Government
Berkowitz, Natacha
1. South Africa, Cape Town Social Services Directorate
McCarthy, Kerrigan Mary
1. South Africa, Johannesburg National Institute for Communicable Diseases
Maseti, Elizabeth
1. South Africa, Pretoria Department of Health, Pretoria
Kamupira, Mercy G.S.
1. Switzerland, Geneva Organisation Mondiale de la Santé
Dlamini, Nonhlanhla R.
1. South Africa, Pretoria Department of Health, Pretoria
Gumede, Nicksy
1. Congo, Brazzaville World Health Organization Regional Office for Africa Congo
Diop, Ousmane Madiagne
1. Switzerland, Geneva Organisation Mondiale de la Santé
Lau, Yu Lung
1. Hong Kong, Hong Kong The University of Hong Kong
Moonsamy, Shelina
1. South Africa, Johannesburg National Institute for Communicable Diseases
Eley, Brian S.
1. South Africa, Cape Town University of Cape Town
Suchard, Melinda Shelley
1. South Africa, Johannesburg National Institute for Communicable Diseases
2. South Africa, Johannesburg School of Pathology

AFRICAN RESEARCH NEXUS

Accelerated Immunodeficiency-associated Vaccine-derived Poliovirus Serotype 3 Sequence Evolution Rate in an 11-week-old Boy with X-linked Agammaglobulinemia and Perinatal Human Immunodeficiency Virus Exposure

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AFRICAN RESEARCH NEXUS

Accelerated Immunodeficiency-associated Vaccine-derived Poliovirus Serotype 3 Sequence Evolution Rate in an 11-week-old Boy with X-linked Agammaglobulinemia and Perinatal Human Immunodeficiency Virus Exposure

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