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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Serum cholesterol levels and the risk of brain natriuretic peptide-diagnosed heart failure in postmenopausal women: a population-based prospective cohort study
Menopause, Volume 30, No. 8, Year 2023
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Description
Objective Hormonal changes during menopause can disturb serum cholesterol which is closely associated with cardiovascular disease. This study investigated the prospective association between serum cholesterol and heart failure (HF) risk in postmenopausal women. Methods We analyzed data from 1,307 Japanese women, aged 55 to 94 years. All women had no history of HF, and their baseline brain natriuretic peptide (BNP) levels were less than 100 pg/mL. During the follow-ups conducted every 2 years, HF was diagnosed among women who developed BNP of 100 pg/mL or greater. Cox proportional hazard models were applied to calculate hazard ratios and 95% CI of HF for women per their baseline total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol (HDL-C) levels. The Cox regression models were adjusted for age, body mass index, smoking, alcohol drinking, hypertension, diabetes, cardiac murmurs, arrhythmia, stroke or ischemic heart disease, chronic kidney disease, and lipid-lowering agent use. Results Within an 8-year median follow-up, 153 participants developed HF. In the multivariable-adjusted model, women with total cholesterol of 240 mg/dL or greater (compared with 160-199 mg/dL) and HDL-C of 100 mg/dL or greater (compared with 50-59 mg/dL) showed an increased risk of HF: hazard ratios (95% CI) = 1.70 (1.04-2.77) and 2.70 (1.10-6.64), respectively. The results remained significant after further adjusting for baseline BNP. No associations were observed with low-density lipoprotein cholesterol. Conclusions Total cholesterol of 240 mg/dL or greater and HDL-C of 100 mg/dL or greater were positively associated with the risk of HF in postmenopausal Japanese women. © Wolters Kluwer Health, Inc. All rights reserved.
Authors & Co-Authors
Arafa, Ahmed Emadeldin
Japan, Suita
National Cerebral and Cardiovascular Center
Egypt, Beni Suef
Beni-suef University
Kashima, Rena
Japan, Suita
National Cerebral and Cardiovascular Center
Japan, Suita
Osaka University
Kokubo, Yoshihiro
Japan, Suita
National Cerebral and Cardiovascular Center
Teramoto, Masayuki
Japan, Suita
National Cerebral and Cardiovascular Center
Japan, Suita
Osaka University
Sakai, Yukie
Japan, Suita
National Cerebral and Cardiovascular Center
Nosaka, Saya
Japan, Suita
National Cerebral and Cardiovascular Center
Kawachi, Haruna
Japan, Suita
National Cerebral and Cardiovascular Center
Japan, Tokyo
Tokyo Medical University Hospital
Shimamoto, Keiko
Japan, Suita
National Cerebral and Cardiovascular Center
Matsumoto, Chisa
Japan, Tokyo
Tokyo Medical University Hospital
Nakao, Yoko M.
Japan, Suita
National Cerebral and Cardiovascular Center
United Kingdom, Leeds
University of Leeds
Gao, Qi
Japan, Suita
National Cerebral and Cardiovascular Center
Izumi, Chisato
Japan, Suita
National Cerebral and Cardiovascular Center
Statistics
Citations: 1
Authors: 12
Affiliations: 5
Identifiers
Doi:
10.1097/GME.0000000000002215
ISSN:
10723714
Research Areas
Environmental
Noncommunicable Diseases
Sexual And Reproductive Health
Substance Abuse
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Participants Gender
Female