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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Evolution of recombination in eutherian mammals: Insights into mechanisms that affect recombination rates and crossover interference
Proceedings of the Royal Society B: Biological Sciences, Volume 280, No. 1771, Article 20131945, Year 2013
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Description
Recombination allows faithful chromosomal segregation during meiosis and contributes to the production of new heritable allelic variants that are essential for the maintenance of genetic diversity. Therefore, an appreciation of how this variation is created and maintained is of critical importance to our understanding of biodiversity and evolutionary change. Here, we analysed the recombination features from species representing the major eutherian taxonomic groups Afrotheria, Rodentia, Primates and Carnivora to better understand the dynamics of mammalian recombination. Our results suggest a phylogenetic component in recombination rates (RRs), which appears to be directional, strongly punctuated and subject to selection. Species that diversified earlier in the evolutionary tree have lower RRs than those from more derived phylogenetic branches. Furthermore, chromosome-specific recombination maps in distantly related taxa show that crossover interference is especially weak in the species with highest RRs detected thus far, the tiger. This is the first example of a mammalian species exhibiting such low levels of crossover interference, highlighting the uniqueness of this species and its relevance for the study of the mechanisms controlling crossover formation, distribution and resolution. © 2013 The Author(s) Published by the Royal Society. All rights reserved.
Authors & Co-Authors
Segura, Joana
Spain
Institut de Biotecnologia I Biomedicina Ibb
Ferretti, Luca
Spain, Cerdanyola Del Valles
Centre for Research in Agricultural Genomics Crag Csic-irta-uab-ub
Ramos-Onsins, Sebastian
Spain, Cerdanyola Del Valles
Centre for Research in Agricultural Genomics Crag Csic-irta-uab-ub
Capilla, Laia
Spain
Institut de Biotecnologia I Biomedicina Ibb
Farré, Marta
Spain, Cerdanyola Del Valles
Departament de Biologia Cellular
United Kingdom, London
Royal Veterinary College University of London
Reis, Fernanda
Spain, Cerdanyola Del Valles
Departament de Biologia Cellular
Oliver-Bonet, Maria
Spain, Cerdanyola Del Valles
Departament de Biologia Cellular
Fernández-Bellon, Hugo
Spain, Barcelona
Parc Zoològic de Barcelona
Garcia, Francisca
Spain, Cerdanyola Del Valles
Universitat Autònoma de Barcelona
Garcia-Caldés, Montserrat
Spain
Institut de Biotecnologia I Biomedicina Ibb
Spain, Cerdanyola Del Valles
Departament de Biologia Cellular
Robinson, Terence J.
South Africa, Stellenbosch
Stellenbosch University
Ruiz-Herrera, Aurora
Spain
Institut de Biotecnologia I Biomedicina Ibb
Spain, Cerdanyola Del Valles
Departament de Biologia Cellular
Statistics
Citations: 81
Authors: 12
Affiliations: 7
Identifiers
Doi:
10.1098/rspb.2013.1945
ISSN:
09628452
e-ISSN:
14712954
Research Areas
Genetics And Genomics