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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Mycobacterium tuberculosis H37Ra and H37Rv differential growth and cytokine/chemokine induction in murine macrophages in vitro
Journal of Interferon and Cytokine Research, Volume 26, No. 1, Year 2006
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Description
The role of tumor necrosis factor-α (TNF-α) in controlling growth of Mycobacterium tuberculosis in murine peritoneal macrophages infected in vitro was studied. TNF-α was shown to be required but not sufficient, and the amount of TNF-α produced by the infected cells did not correlate with the extent of growth control. In this system, TNF-α-dependent control of growth of the avirulent strain H37Ra was independent of inducible nitric oxide synthase (iNOS) and interferon-γ (IFN-γ), as shown by the infection of macrophages from selected gene-disrupted mice. TNF-α-mediated bacteriostasis of H37Ra in the infected macrophages was associated with increased expression of selected Th1-type cytokines and chemokines. In contrast, growth of the virulent strain H37Rv in macrophages involved upregulation by infected cells of Th2-type cytokines, including interleukin-5 (IL-5), IL-10, and IL-13. Taken together, these results suggest that the particular nature of macrophage activation and the cytokine and chemokine response to infection with different M. tuberculosis strains determine the ability of the cells to control the growth of the intracellular bacilli. © Mary Ann Liebert, Inc.
Authors & Co-Authors
Freeman, Sherry L.
United States, Newark
Public Health Research Institute
Post, Frank A.
United Kingdom, London
King's College London
South Africa, Cape Town
University of Cape Town
Bekker, Linda-Gail Gail
South Africa, Cape Town
University of Cape Town
Harbacheuski, Ryhor
United States, Newark
Public Health Research Institute
Steyn, Lafras M.
South Africa, Cape Town
University of Cape Town
Ryffel, Bernhard
South Africa, Cape Town
University of Cape Town
Connell, Nancy D.
United States, Newark
Rutgers Biomedical and Health Sciences
Kreiswirth, Barry N.
United States, Newark
Public Health Research Institute
Kaplan, Gilla
United States, Newark
Public Health Research Institute
Statistics
Citations: 53
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1089/jir.2006.26.27
ISSN:
10799907
Research Areas
Cancer
Genetics And Genomics