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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Rapid Progressing Allele HLA-B35 Px Restricted Anti-HIV-1 CD8+ T Cells Recognize Vestigial CTL Epitopes
PLoS ONE, Volume 5, No. 4, Article e10249, Year 2010
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Description
Background: The HLA-B*35-Px allele has been associated with rapid disease progression in HIV-1 infection, in contrast to the HLA-B*35-Py allele. Methodology/Principal Findings: Immune responses to two HLA-B*35 restricted HIV-1 specific CTL epitopes and their variants were followed longitudinally during early HIV-1 infection in 16 HLA-B*35+ individuals. Subjects expressing HLAB* 35-Px alleles showed no difference in response to the consensus epitopes compared to individuals with HLA-B*35-Py alleles. Surprisingly, all the HLA-B*35-Px+ individuals responded to epitope-variants even in the absence of a consensus response. Sequencing of the viral population revealed no evidence of variant virus in any of the individuals. Conclusions/Significance: This demonstrates a novel phenomenon that distinguishes individuals with the HLA-B*35-Px rapid progressing allele and those with the HLA-B*35-Py slower progressing allele. © 2010 Willberg et al.
Authors & Co-Authors
Willberg, Christian B.
United States, San Francisco
Ucsf School of Medicine
Garrison, Keith E.
United States, San Francisco
Ucsf School of Medicine
Jones, R. Brad
Canada, Toronto
University of Toronto
Meiklejohn, Duncan J.
United States, San Francisco
Ucsf School of Medicine
Spotts, Gerald E.
United States, San Francisco
Ucsf School of Medicine
Liegler, Teri J.
United States, San Francisco
Ucsf School of Medicine
Ostrowski, Mario A.
Canada, Toronto
University of Toronto
Karlsson, Annika C.
Sweden, Stockholm
Karolinska Institutet
Swaziland, Solna
The Swedish Institute for Infectious Disease Control
Hecht, Frederick M.
United States, San Francisco
Ucsf School of Medicine
Nixon, Douglas F.
United States, San Francisco
Ucsf School of Medicine
Statistics
Citations: 18
Authors: 10
Affiliations: 4
Identifiers
Doi:
10.1371/journal.pone.0010249
e-ISSN:
19326203
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study