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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Comparative susceptibility to Plasmodium falciparum of the molecular forms M and S of Anopheles gambiae and Anopheles arabiensis
Malaria Journal, Volume 10, Article 269, Year 2011
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Description
Background: The different taxa belonging to Anopheles gambiae complex display phenotypic differences that may impact their contribution to malaria transmission. More specifically, their susceptibility to infection, resulting from a co-evolution between parasite and vector, might be different. The aim of this study was to compare the susceptibility of M and S molecular forms of Anopheles gambiae and Anopheles arabiensis to infection by Plasmodium falciparum. Methods. F3 progenies of Anopheles gambiae s.l. collected in Senegal were infected, using direct membrane feeding, with P. falciparum gametocyte-containing blood sampled on volunteer patients. The presence of oocysts was determined by light microscopy after 7 days, and the presence of sporozoite by ELISA after 14 days. Mosquito species and molecular forms were identified by PCR. Results: The oocyst rate was significantly higher in the molecular S form (79.07%) than in the M form (57.81%, Fisher's exact test p < 0.001) and in Anopheles arabiensis (55.38%, Fisher's exact test vs. S group p < 0.001). Mean s.e.m. number of oocyst was greater in the An. gambiae S form (1.72 0.26) than in the An. gambiae M form (0.64 0.04, p < 0.0001) and in the An. arabiensis group (0.58 0.04, vs. S group, p < 0.0001). Sporozoite rate was also higher in the molecular form S (83.52%) than in form M (50.98%, Fisher's exact test p < 0.001) and Anopheles arabiensis 50.85%, Fisher's exact test vs. S group p < 0.001). Conclusion: Infected in the same experimental conditions, the molecular form S of An. gambiae is more susceptible to infection by P. falciparum than the molecular form M of An. gambiae and An. arabiensis. © 2011 Ndiath et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Ndiath, Mamadou Ousmane
France, Marseille
Unité de Recherche Sur Les Maladies Infectieuses et Tropicales Emergentes
Cohuet, Anna
France, Montpellier
Maladies Infectieuses et Vecteurs : Écologie, Génétique, Évolution et Contrôle
Gaye, Abdoulaye
France, Marseille
Unité de Recherche Sur Les Maladies Infectieuses et Tropicales Emergentes
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Konaté, Lassana
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Mazenot, Catherine
France, Marseille
Unité de Recherche Sur Les Maladies Infectieuses et Tropicales Emergentes
Faye, Ousmane C.
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Boudin, Christian
France, Marseille
Unité de Recherche Sur Les Maladies Infectieuses et Tropicales Emergentes
Sokhna, Cheikh Sadibou
France, Marseille
Unité de Recherche Sur Les Maladies Infectieuses et Tropicales Emergentes
Trape, Jean François
France, Marseille
Unité de Recherche Sur Les Maladies Infectieuses et Tropicales Emergentes
Statistics
Citations: 42
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1186/1475-2875-10-269
e-ISSN:
14752875
Research Areas
Infectious Diseases
Study Locations
Senegal