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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Cardiopulmonary responses to exercise and its utility in patients with aortic stenosis
American Journal of Cardiology, Volume 113, No. 10, Year 2014
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Description
Utility of cardiopulmonary exercise test is unknown in patients with aortic stenosis. In this retrospective study, we examined the maximal indexes of cardiopulmonary testing at peak exercise in 155 consecutive patients with aortic valve area of ≤amp;1.5 cm;bsupesup who were referred for this test. The patients were passively followed up to assess their effect on the primary end point of all-cause mortality. We found that the absolute peak oxygen consumption (VO;bsubesub) was significantly reduced in these patients, with age and gender-predicted peak VO;bsubesub of 80 ± 23%. Peak VO;bsubesub was markedly reduced (<80% of predicted) in 54% of patients. During a follow-up of 5 ± 4 years, a total of 41 patients died, and 72 underwent aortic valve replacement. Survival was significantly better in patients with higher absolute peak VO;bsubesub (hazard ratio [HR] 0.87, 95% confidence interval [CI] 0.80 to 0.93, p <0.001) and higher oxygen pulse (HR 0.80, 95% CI 0.74 to 0.9, p <0.001). In 83 patients who did not undergo valve replacement, higher peak VO;bsubesub and oxygen pulse were associated with better survival (HR 0.83, 95% CI 0.71 to 0.97, p = 0.024 and HR 0.80, 95% CI 0.66 to 0.96, p = 0.02, respectively). In conclusion, the peak VO;bsubesub is significantly reduced in patients with aortic stenosis. Higher peak VO;bsubesub is independently associated with better survival in these patients irrespective of whether they undergo valve replacement. © 2014 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Dhoble, Abhijeet
United States, Los Angeles
Cedars-sinai Medical Center
United States, Rochester
Mayo Clinic
Enriquez-Sarano, Maurice
United States, Rochester
Mayo Clinic
Kopecky, Stephen L.
United States, Rochester
Mayo Clinic
Abdelmoneim, Sahar S.
United States, Rochester
Mayo Clinic
Egypt, Asyut
Assiut University
Cruz, Paulina
United States, Rochester
Mayo Clinic
Thomas, Randal
United States, Rochester
Mayo Clinic
Allison, Thomas G.
United States, Rochester
Mayo Clinic
Statistics
Citations: 22
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1016/j.amjcard.2014.02.027
ISSN:
00029149
e-ISSN:
18791913
Research Areas
Environmental
Study Design
Cohort Study