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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Nationwide retrospective mortality and seroprevalence of SARS-CoV-2 antibodies in Cameroon
Scientific African, Volume 22, Article e01925, Year 2023
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Description
Background: Although the first year of the COVID-19 pandemic in Africa did not produce the expected catastrophe, the true impact of COVID-19 in the Cameroonian population was unclear. We therefore assessed the seroprevalence of anti-SARS-CoV-2 antibodies and retrospective mortality in a representative sample of the general population in the 10 administrative regions of Cameroon more than one year after the first confirmed cases of COVID-19 in these regions. We aimed to assess the extent of SARS-COV-2 infection and to detect potential increases in the crude mortality rate (CMR) during the SARS-COV-2 pandemic phase. Methods: We assessed retrospective mortality and seroprevalence of anti-SARS-CoV-2 antibodies in the 10 capital cities of Cameroon using representative samples of the general population. The study included nested anti-SARS-CoV-2 antibody prevalence surveys and retrospective mortality surveys and was conducted between 27 July 2021 and 31 August 2021. To further analyze crude mortality rates by age group and COVID wave, pre-pandemic and pandemic periods were stratified. Both laboratory-based assays (ELFA) and rapid diagnostic tests (RDT) were used to measure anti-SARS-CoV-2 seroprevalence. Results: The crude mortality rate (CMR) increased from 0.06 deaths per 10 000 persons per day (pre-pandemic) to 0.17 deaths per 10 000 persons per day (pandemic). The increase in CMR was more pronounced in people aged 20–35 years (pre-pandemic 0.02 deaths per 10 000 persons per day; pandemic 0.06 deaths per 10 000 persons per day). The estimated seroprevalence among unvaccinated persons was 9.5 % (RDT) and 15.4 % (laboratory-based). Conclusion: The seroprevalence results showed that cases were significantly underdetected by the national surveillance systems. © 2023
Authors & Co-Authors
Eyong, Justin
France, Paris
Epicentre
Fai, Karl Njuwa
France, Paris
Epicentre
Nikolay, Birgit
France, Paris
Epicentre
Gignoux, Etienne Marc Hugues
France, Paris
Epicentre
Nsaibirni, Robert F.J.
France, Paris
Epicentre
Yuya, Francis
France, Paris
Epicentre
Youm, Eric
France, Paris
Epicentre
Ntonè, Rodrigue
France, Paris
Epicentre
Mbarga, Nicole Fouda
Switzerland, Geneva
Medecins Sans Frontieres
Matchim, Lucrece
France, Paris
Epicentre
Tchiasso, Dora
France, Paris
Epicentre
Yonta, Cyrille
France, Paris
Epicentre
Ndifon, Mark
France, Paris
Epicentre
Essomba, Rene Ghislain
Cameroon, Yaounde
National Public Health Laboratory
Cameroon, Yaounde
Université de Yaoundé I
Wanda, Franck
Unknown Affiliation
Mandeng, Nadia
Cameroon, Yaounde
Ministry of Health Cameroon
Essaka, Rachel
Cameroon, Yaounde
Laboratoire du Lac
Koku, Modeste Tamakloé
Switzerland, Geneva
Medecins Sans Frontieres
Eyangoh, Sara Irène
Cameroon, Yaounde
Centre Pasteur du Cameroun
Ousman, Moussa
Cameroon, Yaounde
Laboratoire du Lac
Esso, Linda
Cameroon, Yaounde
Université de Yaoundé I
Cameroon, Yaounde
Ministry of Health Cameroon
Epée, Émilienne E.E.
Cameroon, Yaounde
Ministry of Health Cameroon
Njouom, Richard
Cameroon, Yaounde
Centre Pasteur du Cameroun
Okomo, Marie Claire Assoumou
Cameroon, Yaounde
National Public Health Laboratory
Cameroon, Yaounde
Université de Yaoundé I
Ciglenečki, Iza
Switzerland, Geneva
Medecins Sans Frontieres
Mballa, Georges Alain Etoundi
Cameroon, Yaounde
Ministry of Health Cameroon
Porten, Klaudia
France, Paris
Epicentre
Boum, Yap I.
France, Paris
Epicentre
Cameroon, Yaounde
Université de Yaoundé I
Cameroon, Yaounde
Ministry of Health Cameroon
Statistics
Authors: 28
Affiliations: 7
Identifiers
Doi:
10.1016/j.sciaf.2023.e01925
ISSN:
24682276
Research Areas
Covid
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Cameroon