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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
HLA and non-HLA genes in Behçet's disease: A multicentric study in the Spanish population
Arthritis Research and Therapy, Volume 15, No. 5, Article R145, Year 2013
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Description
Introduction: According to genome wide association (GWA) studies as well as candidate gene approaches, Behçet's disease (BD) is associated with human leukocyte antigen (HLA)-A and HLA-B gene regions. The HLA-B51 has been consistently associated with the disease, but the role of other HLA class I molecules remains controversial. Recently, variants in non-HLA genes have also been associated with BD. The aims of this study were to further investigate the influence of the HLA region in BD and to explore the relationship with non-HLA genes recently described to be associated in other populations.Methods: This study included 304 BD patients and 313 ethnically matched controls. HLA-A and HLA-B low resolution typing was carried out by PCR-SSOP Luminex. Eleven tag single nucleotide polymorphisms (SNPs) located outside of the HLA-region, previously described associated with the disease in GWA studies and having a minor allele frequency in Caucasians greater than 0.15 were genotyped using TaqMan assays. Phenotypic and genotypic frequencies were estimated by direct counting and distributions were compared using the χ2 test.Results: In addition to HLA-B*51, HLA-B*57 was found as a risk factor in BD, whereas, B*35 was found to be protective. Other HLA-A and B specificities were suggestive of association with the disease as risk (A*02 and A*24) or protective factors (A*03 and B*58). Regarding the non-HLA genes, the three SNPs located in IL23R and one of the SNPs in IL10 were found to be significantly associated with susceptibility to BD in our population.Conclusion: Different HLA specificities are associated with Behçet's disease in addition to B*51. Other non-HLA genes, such as IL23R and IL-10, play a role in the susceptibility to the disease. © 2013 Montes-Cano et al.; licensee BioMed Central Ltd.
Authors & Co-Authors
Conde-Jaldón, Marta
Spain, Sevilla
Csic-ja-use - Instituto de Biomedicina de Sevilla
Ortiz-Fernández, Lourdes
Spain, Sevilla
Csic-ja-use - Instituto de Biomedicina de Sevilla
Ortego-Centeno, Norberto
Spain, Granada
Hospital Universitario San Cecilio
Espinosa, Gerard
Spain, Barcelona
Hospital Clinic Barcelona
González-Gay, Miguel Ángel
Spain, Santander
Hospital Universitario Marqués de Valdecilla
Solans-Laqué, Roser
Spain, Barcelona
Hospital Clinic Barcelona
Castañeda, Santos
Spain, Madrid
Hospital Universitario de la Princesa
Martin, Javier
Unknown Affiliation
Gónzalez-Escribano, María Francisca
Spain, Sevilla
Csic-ja-use - Instituto de Biomedicina de Sevilla
Statistics
Citations: 42
Authors: 9
Affiliations: 10
Identifiers
Doi:
10.1186/ar4328
ISSN:
14786362
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study