Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
A multicenter, randomized trial of noninvasive ventilation with helium-oxygen mixture in exacerbations of chronic obstructive lung disease
Critical Care Medicine, Volume 38, No. 1, Year 2010
Notification
URL copied to clipboard!
Description
OBJECTIVE: To assess the effect of a helium-oxygen mixture on intubation rate and clinical outcomes during noninvasive ventilation in acute exacerbation of chronic obstructive pulmonary disease. DESIGN: Multicenter, prospective, randomized, controlled trial. SETTING: Seven intensive care units. PATIENTS: A total of 204 patients with known or suspected chronic obstructive pulmonary disease and acute dyspnea, Paco2> 45 mm Hg and two among the following factors: pH <7.35, Paco2 <50 mm Hg, respiratory rate >25/min. INTERVENTIONS: Noninvasive ventilation randomly applied with or without helium (inspired oxygen fraction 0.35) via a face mask. MEASUREMENTS AND MAIN RESULTS: Duration and complications of NIV and mechanical ventilation, endotracheal intubation, discharge from intensive care unit and hospital, mortality at day 28, adverse and serious adverse events were recorded. Follow-up lasted until 28 days since enrollment. Intubation rate did not significantly differ between groups (24.5% vs. 30.4% with or without helium, p =.35). No difference was observed in terms of improvement of arterial blood gases, dyspnea, and respiratory rate between groups. Duration of noninvasive ventilation, length of stay, 28-day mortality, complications and adverse events were similar, although serious adverse events tended to be lower with helium (10.8% vs. 19.6%, p =.08). CONCLUSIONS: Despite small trends favoring helium, this study did not show a statistical superiority of using helium during NIV to decrease the intubation rate in acute exacerbation of chronic obstructive pulmonary disease. Copyright © 2009 by the Society of Critical Care Medicine and Lippincott Williams & Wilkins.
Authors & Co-Authors
Maggiore, Salvatore Maurizio
Italy, Rome
Fondazione Policlinico Universitario Agostino Gemelli Irccs
France, Creteil
Hôpital Henri Mondor
Richard, Jean Christophe Marie
France, Rouen
Hopital Charles Nicolle
France, Rouen
Grhv - Groupe de Recherche Sur le Handicap Ventilatoire
Abrouk, Fekri
Tunisia, Monastir
Chu Fattouma-bourguiba
Diehl, Jean Luc
France, Paris
Hôpital Européen Georges-pompidou
Antonelli, Massimo M.
Italy, Rome
Fondazione Policlinico Universitario Agostino Gemelli Irccs
Sauder, Philippe
France, Strasbourg
Civils Hospices
Mancebo, Jordi B.Y.J.
Spain, Barcelona
Hospital Sant Pau
Ferrer, Miquel
Spain, Barcelona
Clinic University Hospital
Lellouche, François
Unknown Affiliation
Lecourt, Laurent
France, Paris
Air Liquide
Béduneau, Gaëtan
France, Rouen
Hopital Charles Nicolle
Brochard, Laurent Jean
France, Creteil
Hôpital Henri Mondor
France, Creteil
Université Paris-est Créteil Val de Marne
France, Creteil
Institut Mondor de Recherche Biomédicale
Statistics
Citations: 50
Authors: 12
Affiliations: 12
Identifiers
Doi:
10.1097/CCM.0b013e3181b78abe
ISSN:
00903493
e-ISSN:
15300293
Research Areas
Health System And Policy
Study Design
Cohort Study