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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Occupational exposure to aluminum and its amyloidogenic link with cognitive functions
Journal of Inorganic Biochemistry, Volume 139, Year 2014
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Description
As many other metals, aluminum is a widely recognized neurotoxicant and its link with neurodegenerative disorders has been the subject of scientific debate. One proposal focuses on amyloid β deposition (amyloidogenesis) as the key player in triggering neuronal dysfunction the so-called amyloid cascade hypothesis. We undertook this study first to investigate the cognition status of workers exposed to Al dust in an Al factory in Southern Cairo, second, to evaluate serum amyloid precursor protein (APP) and cathepsin D (CD) enzyme activity to study the possible role of Al in amyloidogenesis, and finally to explore the relation between these potential biomarkers and cognitive functions. The study was conducted on 54 exposed workers and 51 matched controls. They were subjected to questionnaire, neurological examination and a cognitive test battery, Addenbrooke's Cognitive Examination - Revised (ACE-R). Serum Al, APP and CD enzyme activity were measured. A significant increase of serum Al was found in the exposed workers with an associated increase in serum APP and decrement in CD activity. The exposed workers displayed poor performance on the ACE-R test. No significant correlation was detected between ACE-R test total score and either APP or CD activity. We concluded that occupational exposure to Al is associated with cognitive impairment. The effect of occupational Al exposure on the serum levels of APP and CD activity may be regarded as a possible mechanism of Al in amyloidogenesis. However, our findings do not support the utility of serum APP and CD activity as screening markers for early or preclinical cognitive impairment. © 2014 Elsevier Inc.
Authors & Co-Authors
Zawilla, N. H.
Egypt, Cairo
Faculty of Medicine
Taha, Fatma Mohamed
Egypt, Cairo
Faculty of Medicine
Kishk, Nirmeen Adel
Egypt, Cairo
Faculty of Medicine
Farahat, S. A.
Egypt, Cairo
Faculty of Medicine
Farghaly, Marwa
Egypt, Cairo
Faculty of Medicine
Hussein, Mona Abd Elmotaleb A.
Egypt, Beni Suef
Faculty of Medicine
Statistics
Citations: 35
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1016/j.jinorgbio.2014.06.003
ISSN:
01620134
e-ISSN:
18733344