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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Neutralization of Vipera and Macrovipera venoms by two experimental polyvalent antisera: A study of paraspecificity
Toxicon, Volume 57, No. 7-8, Year 2011
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Description
We conducted an extensive study of neutralization of lethality of 11 species and one subspecies of snakes of the genus Vipera, and of five species of Macrovipera, by two experimental equine antisera. One antiserum was a trivalent preparation raised against the venoms of Vipera aspis aspis, Vipera berus berus and Vipera ammodytes ammodytes; the other was a pentavalent preparation that also included venoms of Vipera (now Montivipera) xanthina and Macrovipera lebetina obtusa. We measured specific neutralization of lethality against all venoms included in the immunization schemes, and paraspecific neutralization against the venoms of Vipera ammodytes montandoni, Vipera (Montivipera) bornmuelleri, Vipera latastei, Vipera (Mo.) latifii, Vipera (Mo.) lotievi, Vipera (Daboia) palaestinae, Vipera (Mo.) raddei and Vipera seoanei, as well as against Macrovipera (D.) deserti, Macrovipera lebetina cernovi, Macrovipera lebetina turanica and Macrovipera schweitzeri. We found an important degree of paraspecific protection within each genera (omitting recent reclassification) that was quite independent of both the lethal potency of the venoms and their geographic origin. This information may be of use to clinicians charged with the treatment of Vipera or Macrovipera envenomations with non-specific antivenoms. © 2011 Elsevier Ltd.
Authors & Co-Authors
Chippaux, Jean Philippe
France, Marseille
Ird Institut de Recherche Pour le Developpement
Alagon, A. C.
Mexico, Cuernavaca
Universidad Nacional Autónoma de México Campus Morelos
Stock, Roberto Pablo
Mexico, Cuernavaca
Universidad Nacional Autónoma de México Campus Morelos
Statistics
Citations: 28
Authors: 3
Affiliations: 4
Identifiers
Doi:
10.1016/j.toxicon.2011.04.009
ISSN:
18793150
Research Areas
Maternal And Child Health