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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Optimisation and characterisation of bioadhesive controlled release tetracycline microspheres
International Journal of Pharmaceutics, Volume 306, No. 1-2, Year 2005
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Description
A Box-Behnken experimental design was employed to statistically optimise the formulation parameters of a tetracycline microsphere preparation for maximum bioadhesivity and controlled drug release. The quantitative effect of the formulation parameters at different levels on bioadhesion and drug release could be predicted using polynomial equations. A formulation comprising of 3% (w/w) chitosan, 10% (w/w) tetracycline HCl and 9% (w/v) tripolyphosphate was identified for maximising bioadhesivity and obtaining controlled drug release. The optimal microsphere preparation was subsequently characterised in terms of hydration dynamics, release kinetics, antimicrobial activity, thermal properties, morphology and surface pH. Kinetic models revealed that drug release followed Fickian diffusion while textural analysis showed minimal hydration over the test period. Antimicrobial studies showed that the drug concentrations in the in vitro release samples were above the minimum concentration of drug required for inhibition of Staphylococcus aureus growth. Thermal analyses showed a possible interaction between the drug and polymer. Scanning electron microscopy confirmed the integrity of the microspheres and identified the morphological changes following drug release. Surface pH of the microspheres was similar to salivary pH and did not show extremes in changes over the test period. © 2005 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Govender, Suendran
South Africa, Durban
University of Kwazulu-natal
Pillay, Viness
South Africa, Johannesburg
University of the Witwatersrand
Chetty, D. J.
United States, Philadelphia
Glaxosmithkline, Usa
Essack, Sabiha Y.
South Africa, Durban
University of Kwazulu-natal
Dangor, Cassim M.
South Africa, Durban
University of Kwazulu-natal
Govender, Thirumala
South Africa, Durban
University of Kwazulu-natal
Statistics
Citations: 169
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1016/j.ijpharm.2005.07.026
ISSN:
03785173
Study Approach
Quantitative