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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
A field guide to pandemic, epidemic and sporadic clones of methicillin-resistant Staphylococcus aureus
PLoS ONE, Volume 6, No. 4, Article e17936, Year 2011
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Description
In recent years, methicillin-resistant Staphylococcus aureus (MRSA) have become a truly global challenge. In addition to the long-known healthcare-associated clones, novel strains have also emerged outside of the hospital settings, in the community as well as in livestock. The emergence and spread of virulent clones expressing Panton-Valentine leukocidin (PVL) is an additional cause for concern. In order to provide an overview of pandemic, epidemic and sporadic strains, more than 3,000 clinical and veterinary isolates of MRSA mainly from Germany, the United Kingdom, Ireland, France, Malta, Abu Dhabi, Hong Kong, Australia, Trinidad & Tobago as well as some reference strains from the United States have been genotyped by DNA microarray analysis. This technique allowed the assignment of the MRSA isolates to 34 distinct lineages which can be clearly defined based on non-mobile genes. The results were in accordance with data from multilocus sequence typing. More than 100 different strains were distinguished based on affiliation to these lineages, SCCmec type and the presence or absence of PVL. These strains are described here mainly with regard to clinically relevant antimicrobial resistance- and virulence-associated markers, but also in relation to epidemiology and geographic distribution. The findings of the study show a high level of biodiversity among MRSA, especially among strains harbouring SCCmec IV and V elements. The data also indicate a high rate of genetic recombination in MRSA involving SCC elements, bacteriophages or other mobile genetic elements and large-scale chromosomal replacements. © 2011 Monecke et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3071808/bin/pone.0017936.s001.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3071808/bin/pone.0017936.s002.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3071808/bin/pone.0017936.s003.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3071808/bin/pone.0017936.s004.nex
https://efashare.b-cdn.net/share/pmc/articles/PMC3071808/bin/pone.0017936.s005.nex
Authors & Co-Authors
Monecke, Stefan
Germany, Dresden
Technische Universität Dresden
Germany, Jena
Alere Technologies Gmbh
Coombs, Geoffrey W.
Australia, Perth
Royal Perth Hospital
Shore, Anna C.
Ireland, Dublin
Dublin Dental University Hospital
Coleman, D. C.
Ireland, Dublin
Dublin Dental University Hospital
Akpaka, Patrick Eberechi
Trinidad and Tobago, St Augustine
The University of the West Indies, St. Augustine Campus
Borg, Michael A.
Malta, Valletta
Mater Dei Hospital
Chow, Henry
Hong Kong, Hong Kong
Chinese University of Hong Kong, Faculty of Medicine
Ip, Margaret P.Y.
Hong Kong, Hong Kong
Chinese University of Hong Kong, Faculty of Medicine
Jatzwauk, Lutz
Germany, Dresden
Universitätsklinikum Carl Gustav Carus Dresden
Jonas, Daniel
Germany, Freiburg Im Breisgau
Universitätsklinikum Freiburg
Kadlec, Kristina
Germany, Tubingen
Friedrich-loeffler-institute
Kearns, Angela Marie
United Kingdom, London
Public Health England
Laurent, Frédéric J.
France, Lyon
Université de Lyon
O'Brien, Frances G.
Australia, Perth
Curtin University
Pearson, Julie C.
Australia, Perth
Royal Perth Hospital
Ruppelt-Lorz, Antje
Germany, Dresden
Technische Universität Dresden
Schwarz, Stefan
Germany, Tubingen
Friedrich-loeffler-institute
Scicluna, Elizabeth Anne
Malta, Valletta
Mater Dei Hospital
Slickers, Peter
Germany, Jena
Alere Technologies Gmbh
Tan, Hui Leen
Australia, Perth
Royal Perth Hospital
Weber, Stefan
United Arab Emirates, Abu Dhabi
Sheikh Khalifa Medical City
Ehricht, Ralf
Germany, Jena
Alere Technologies Gmbh
Statistics
Citations: 846
Authors: 22
Affiliations: 14
Identifiers
Doi:
10.1371/journal.pone.0017936
e-ISSN:
19326203
Research Areas
Genetics And Genomics
Health System And Policy