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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Seroprevalence and risk factors of Chikungunya virus infection in Mayotte, Indian Ocean, 2005-2006: A population- based survey
PLoS ONE, Volume 3, No. 8, Article e3066, Year 2008
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Description
Background: Since 2006, Chikungunya virus (CHIKV) has re-emerged as an important pathogen of global concern. However, individual and household factors associated with the acquisition and the magnitude of clinically silent CHIKV infections remain poorly understood. In this present study, we aimed to investigate the seroprevalence, estimate the proportion of symptomatic illness and identify the risk factors for CHIKV infection in the primo-exposed population of Mayotte. Methods/Principal Findings: We conducted a household-based cross sectional serosurvey in Mayotte in November and December 2006 using complex multistage cluster sampling. To produce the results representative of the island population aged 2 years or older, sample data were adjusted with sample weights. Explanatory and multiple logistic regression analyses were performed to investigate associations between CHIKV infection seropositivity (presence of IgM and/or IgG to CHIKV by enzyme-linked immunoabsorbent assay) and risk factors. A total of 1154 individuals were analyzed. The overall seroprevalence of CHIKV infection was 37-2% (95% CI = 33-9-40-5), 318 (72-3%) of the seropositive participants reported symptoms consistent with a CHIKV infection during the epidemic period. Risk factors for CHIKV seropositivity among adults (aged 15 years and older) were male gender, low socioeconomic index, schooling ≤6 years and living in makeshift housing. Conclusions: Our findings indicate that roughly one out of four CHIKV infections is asymptomatic. Conditions associated with poverty may be considered as critical in CHIKV acquisition. Thus, these conditions should be taken into account in the development of future prevention strategies of CHIKV disease. © 2008 Sissoko et al.
Authors & Co-Authors
Sissoko, Daouda
France, Saint-maurice
Institut de Veille Sanitaire
Moendandzé, Amrat
Unknown Affiliation
Malvy, Denis Jean Marie
France, Bordeaux
Hopital Saint-andre
France, Bordeaux
Université de Bordeaux
Giry, Claude
Mayotte, Mamoudzou
Centre Hospitalier de Mayotte
Ezzedine, Khaled H.
France, Bordeaux
Hopital Saint-andre
France, Bordeaux
Université de Bordeaux
Solet, Jean Louis
France, Saint-maurice
Institut de Veille Sanitaire
Pierre, Vincent
France, Saint-maurice
Institut de Veille Sanitaire
Statistics
Citations: 174
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1371/journal.pone.0003066
e-ISSN:
19326203
Study Design
Cross Sectional Study
Study Approach
Quantitative
Participants Gender
Male