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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Neutralizing monoclonal antibodies to human immunodeficiency virus type 1 do not inhibit viral transcytosis through mucosal epithelial cells
Virology, Volume 370, No. 2, Year 2008
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Description
HIV-1 transcytosis has been proposed as a potential mechanism allowing the virus to cross the epithelium during mucosal transmission. Epitopes of the HIV-1 envelope involved in this process have not been identified yet. Here, we assessed a large panel of HIV neutralizing antibodies recognizing well-characterized epitopes of the HIV-1 envelope for their ability to block HIV-1 transcytosis across a confluent epithelial monolayer. We found that all of the 13 HIV-1-specific monoclonal antibodies tested in the present study, including the three broadly neutralizing antibodies 2F5, 2G12 and IgG1b12, lacked the ability to inhibit transcytosis of cell-free and cell-associated R5- as X4-tropic HIV-1 across a tight and polarized monolayer of HEC-1 epithelial cells. In contrast, anti-gp160 polyclonal antibodies purified from serum or breast milk of HIV-1-infected individuals potently inhibited HIV-1 transcytosis. Furthermore, polymeric S-IgA exhibited similar ability to inhibit transcytosis compared to IgG despite their lower anti-gp160 specific activity. Together, these results demonstrate that the major neutralizing envelope epitopes of HIV-1 are not involved in HIV-1 transcytosis, and suggest that surface agglutination of virus particles may participate to the blocking effect observed with both polyclonal and polymeric anti-gp160 immunoglobulins. © 2007 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Chomont, Nicolas
France, Paris
Université Paris Cité
Hocini, Hakim
France, Paris
Université Paris Cité
Gody, Jean Chrysostome
Central African Republic, Bangui
Université de Bangui Faculte Des Sciences de la Sante
Bouhlal, Hicham
France, Paris
Université Paris Cité
Becquart, Pierre
France, Montpellier
Ird Centre de Montpellier
Krief-Bouillet, Corinne
France, Paris
Université Paris Cité
Kazatchkine, Michel Daniel
France, Paris
Université Paris Cité
Bélec, Laurent
France, Paris
Université Paris Cité
Statistics
Citations: 38
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1016/j.virol.2007.09.006
ISSN:
00426822
e-ISSN:
10960341
Research Areas
Infectious Diseases