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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Audit of performance of needle core biopsy diagnoses of screen detected breast lesions
European Journal of Cancer, Volume 44, No. 17, Year 2008
Notification
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Description
Breast needle core biopsy (NCB) is now a standard diagnostic procedure in the triple assessment of screen detected breast lesions. Therefore, it is important to provide robust and up-to-date data on the performance of NCB in the screening setting. However, previous studies of NCB have suffered from either limitation in the number of assessed cases or included a mix of symptomatic and screen detected breast lesions. In this study, we have evaluated the performance of a large series of uniformly assessed NCBs of screen detected lesions (20001 cases) over a period of 10 years (1997-2007). Our results showed a gradual increase in the number of NCBs and an improvement of their performance over the period of the study; absolute sensitivity increased from 84.9% to 96.4% and complete sensitivity increased from 90.9% to 99.7%. There was also a gradual reduction in the number of surgical interventions after benign (B2) and negative (B1) NCB diagnoses. Our study provides data showing variance from the suggested thresholds for the measures of performance of NCB in the United Kingdom which could be used to provide updated evidence-based thresholds for assessment of performance of NCB diagnosis use in the assessment of breast cancer screen detected lesions in the UK and elsewhere. © 2008 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
El-Sayed, Maysa E.
United Kingdom, Nottingham
University of Nottingham
Egypt, Shibin el Kom
Menoufia University Faculty of Medicine
Rakha, Emad A.
United Kingdom, Nottingham
University of Nottingham
Reed, Jacquie A.
United Kingdom, Nottingham
Nottingham University Hospitals Nhs Trust
Lee, Andrew H.S.
United Kingdom, Nottingham
University of Nottingham
Evans, Andrew J.
United Kingdom, Nottingham
Nottingham University Hospitals Nhs Trust
Ellis, Ian O.
United Kingdom, Nottingham
University of Nottingham
Statistics
Citations: 38
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1016/j.ejca.2008.05.024
ISSN:
09598049
Research Areas
Cancer
Health System And Policy