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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
In vitro evaluation of effects of two ghanaian plants relevant to wound healing
Phytotherapy Research, Volume 20, No. 11, Year 2006
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Description
Commelina diffusa and Spathodea campanulata are used as wound-healing agents in Ashanti traditional medicine in Ghana. The methanol extracts of Commelina diffusa herb and Spathodea campanulata bark showed some level of antimicrobial activity with C. diffusa exhibiting selective antifungal activity against Trichophyton species. The extracts reduced the peroxidation of bovine brain extract with an IC50 value of 1.39 mg/mL and 0.24 mg/mL, respectively. In addition the extracts also exhibited significant antioxidant activity by protecting MRC-5 cells from hydrogen peroxide induced oxidant injury at concentrations between 1 μg/mL and 10 μg/mL. The extracts showed no inhibition of NF-κB at 100 μg/mL. The antioxidant activities and antimicrobial activities suggest that the use of the plants in wound healing may be based on antioxidant and antiseptic effects of its constituents. Copyright © 2006 John Wiley & Sons, Ltd.
Authors & Co-Authors
Mensah, Abraham Yeboah
Unknown Affiliation
Houghton, Peter John
Unknown Affiliation
Dickson, Rita Akosua
Unknown Affiliation
Fleischer, Theophilus Christian
Unknown Affiliation
Heinrich, Michael M.
Unknown Affiliation
Bremner, P.
Unknown Affiliation
Statistics
Citations: 69
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1002/ptr.1978
ISSN:
0951418X
e-ISSN:
10991573
Research Areas
Health System And Policy
Violence And Injury
Study Locations
Ghana