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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
HIV prevention strategies and risk of infection: A model-based analysis
Epidemiology and Infection, Volume 146, No. 8, Year 2018
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Description
Risk populations for HIV infections tend to neglect condom use, making alternative preventive approaches necessary. Accordingly, we modelled the risk of sexual HIV transmission for condom use vs. use of rapid diagnostic test (RDT) systems with subsequent exclusion of potential sexual partners with a correctly or falsely positive test from unprotected sex with and without the use of HIV pre-exposure prophylaxis (PrEP) in a bio-statistical approach. We combined a previously described model of transmission risk for HIV-exposed individuals with a newly suggested model of risk of HIV exposure for sexually active HIV-negative individuals. The model was adapted for several stages of infection and different strategies of HIV infection prevention. HIV prevention with RDTs can reduce the transmission risk by up to 97% compared with having sex without any prevention and up to 80% compared with condom use. Nevertheless, RDT-based prevention strategies demonstrate a lack of protection in several stages of infection; in particular, RNA-based RDT systems may fail under treatment. RDT-based pre-screening of potential sex partners prior to unprotected sexual contacts substantially reduces HIV transmission risk. Combination of different prevention strategies is advisable for high-risk groups. © 2018 Cambridge University Press.
Authors & Co-Authors
Hahn, Andreas
Germany, Berlin
Charité – Universitätsmedizin Berlin
Hinz, Rebecca
Germany, Hamburg
Bundeswehr Hospital Hamburg
Loderstaedt, Ulrike
Germany, Hamburg
Institut Für Hygiene Und Umwelt
Herchenröder, Ottmar
Germany, Rostock
Universität Rostock Uniklinikum Und Medizinische Fakultät
Meyer, Christian G.
Viet Nam, Da Nang
Duy Tan University
Germany, Tubingen
Eberhard Karls Universität Tübingen
Schwarz, Norbert Georg
Germany, Hamburg
Bernhard Nocht Institut Fur Tropenmedizin Hamburg
Frickmann, Hagen
Germany, Hamburg
Bundeswehr Hospital Hamburg
Germany, Rostock
Universität Rostock Uniklinikum Und Medizinische Fakultät
Statistics
Citations: 8
Authors: 7
Affiliations: 8
Identifiers
Doi:
10.1017/S0950268818000845
ISSN:
09502688
Research Areas
Infectious Diseases
Sexual And Reproductive Health
Violence And Injury