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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Increased maternal/fetal blood S100B levels following systemic endotoxin administration and periventricular white matter injury in preterm fetal sheep
Reproductive Sciences, Volume 16, No. 8, Year 2009
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Description
Objective. Intrauterine infection is suggested to cause perinatal brain white matter injury. In the current study, we evaluated whether S100B, a brain damage marker, may be also assessed in maternal bloodstream after white matter injury induced by fetal intravenous application of lypopolisaccharide (LPS) endotoxin. Methods. Fourteen fetal sheeps were chronically catheterized at a mean gestational age of 107 days. Three days after surgery, fetuses (n = 7) received 500 ng of LPS or 2 mL 0.9% saline (n = 7) intravenously (IV). Lypopolisaccharide and placebo groups were monitored by continuous hemodynamic data recordings and at 6 predetermined time points (control value; 3, 6, 24, 48, and 72 hours after LPS/placebo administration) blood was drawn for laboratory parameters and S100B assessment. Brain damage was evaluated by light microscopy after Klüver-Barrera staining. Selected areas of the periventricular white matter were also examined by electron microscopy. Results. White matter injury was detected in all LPS-treated fetuses, whereas no abnormalities were seen in control animals or in LPS-treated mothers. Maternal and fetal S100B protein levels were significantly higher in the LPS group than in the control group at all monitoring time points (P <.001). The highest fetal-maternal S100B levels were observed at 3-hour time-point (P <.001). Conclusions. We found that S100B protein is increased in the maternal district in presence of fetal periventricular brain white matter injury induced by endotoxin. The present data offer additional support for S100B assessment in the maternal circulation in pregnancies complicated by intrauterine infection at risk of white matter injury. © 2009 The Author(s).
Authors & Co-Authors
Garnier, Yves
Germany, Aachen
Uniklinik Rwth Aachen
Netherlands, Maastricht
Maastricht Universitair Medisch Centrum+
Frigiola, Alessandro
Italy, San Donato Milanese
Gruppo Ospedaliero San Donato
Livolti, Giovanni
Italy, Catania
Università Degli Studi Di Catania
Florio, Pasquale
Italy, Siena
Università Degli Studi Di Siena
Frulio, Rosanna
Italy, Genoa
Istituto Giannina Gaslini
Berger, Richard
Germany, Bochum
Ruhr-universitat Bochum
Alm, Stephanie
Germany, Aachen
Uniklinik Rwth Aachen
Von Duering, Monika U.
Germany, Bochum
Ruhr-universitat Bochum
Coumans, Audrey B.C.
Netherlands, Maastricht
Maastricht Universitair Medisch Centrum+
Reis, Fernando M.
Italy, Siena
Università Degli Studi Di Siena
Petraglia, Felice
Italy, Siena
Università Degli Studi Di Siena
Hasaart, Tom H.M.
Netherlands, Maastricht
Maastricht Universitair Medisch Centrum+
Abella, Raúl Felipe
Italy, San Donato Milanese
Gruppo Ospedaliero San Donato
Mufeed, Hala
Egypt, Giza
Cairo University
Gazzolo, Diego
Italy, Genoa
Istituto Giannina Gaslini
Italy, Catania
Ospedale Garibaldi
Italy, Genoa
G. Garibaldi Hospital Catania
Statistics
Citations: 29
Authors: 15
Affiliations: 10
Identifiers
Doi:
10.1177/1933719109335801
ISSN:
19337191
e-ISSN:
19337205
Research Areas
Health System And Policy
Maternal And Child Health
Violence And Injury
Study Design
Randomised Control Trial