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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
In vitro activities of plant extracts on human Loa loa isolates and cytotoxicity for eukaryotic cells
Parasitology Research, Volume 107, No. 3, Year 2010
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Description
Loa loa, a filarial worm, can cause fatal encephalitis in humans. In an attempt to find alternatives to the standard treatments (ivermectin and diethylcarbamazine citrate), we tested 12 methanolic extracts of nine traditional plant remedies. The extracts (100-0.09 μg/ml) were incubated with 20 Loa loa microfilariae isolated from patients at 37°C with 5% CO 2 in modified Eagle's medium supplemented with 10% fetal serum and antibiotics. Activity was evaluated 120 h later by counting live microfilariae under a microscope. Cytotoxicity for eukaryotic cells was estimated by measuring 3-[4,5-dimethylthiazol-2-yl]-2-5 diphenyl tetrazolium bromide transformation to formazan at 450 nM in a spectrophotometer. The plants tested were Lophira alata, Greenwayodendron suaveolens, Uapaca togoensis, Zanthoxylum heitzii, Peperomia pellucida, Piptadeniastrum africanum, Petersianthus macrocarpus, Vernonia conferta, and Vernonia hymenolepis. Chemical screening showed that most of the extracts contained reducing sugars, tannin or polyphenols, sterols or triterpenes, saponosides, and alkaloids. None contained carotinoids and few contained flavonoids. The 50% lethal concentration ranged from 0.22 to 70.28 μg/ml, while the 50% inhibitory concentration for eukaryotic cells (IC 50) ranged from 8.52 to 119.52 μg/ml. Extracts of P. macrocarpus (selectivity index = ;72.16), P. africanum (13.69), Z. heitzii (12.11), and L. alata (9.26) were highly selective for L. loa. © 2010 Springer-Verlag.
Authors & Co-Authors
Mengome, Line Edwige
Gabon
Institut de Pharmacopée et de Médecine Traditionnelle Iphametra
Akué, Jean Paul D.
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Souza, Alain
Gabon
Institut de Pharmacopée et de Médecine Traditionnelle Iphametra
Feuya Tchoua, Guy Raymond
Gabon, Franceville
Université Des Sciences et Techniques Ustm
Nsi-Emvo, Edouard
Gabon, Franceville
Université Des Sciences et Techniques Ustm
Statistics
Citations: 35
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1007/s00436-010-1910-2
ISSN:
09320113