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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The impact of routine infant immunization with Haemophilus influenzae type b conjugate vaccine in Malawi, a country with high human immunodeficiency virus prevalence
Vaccine, Volume 24, No. 37-39, Year 2006
Notification
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Description
Malawi has extreme poverty and a high-human immunodeficiency virus (HIV) prevalence. Following Haemophilus influenzae type b (Hib) conjugate vaccine introduction during 2002, we evaluated vaccine impact by reviewing hospital surveillance data for acute bacterial meningitis in Blantyre district among children age 1-59 months admitted during 1997-2005. Documented annual Hib meningitis incidence rates decreased from 20-40/100,000 to near zero among both rural and urban residents despite no change in pneumococcal meningitis incidence rates. Before vaccine introduction, an average of 10 children/year had Hib meningitis and HIV infection compared to 2/year during 2003-2004 and none during 2005. Vaccine effectiveness was high following two or more doses of vaccine. The most urgent future need is for a sustainable routine infant immunization program, including a less expensive vaccine that preferably is delivered in a multivalent form. © 2006 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Daza, Paul
Malawi, Mzuzu
Mzuzu Central Hospital
Banda, Richard M.
Switzerland, Geneva
Organisation Mondiale de la Santé
Misoya, Keystoxe
Malawi, Blantyre
Queen Elizabeth Central Hospital Malawi
Katsulukuta, Agnes
Malawi, Lilongwe
Ministry of Health Malawai
Gessner, Bradford D.
France, Paris
Institut Pasteur, Paris
Katsande, Regis
Switzerland, Geneva
Organisation Mondiale de la Santé
Mhlanga, Bekithemba
Switzerland, Geneva
Organisation Mondiale de la Santé
Mueller, Judith E.
France, Paris
Institut Pasteur, Paris
Nelson, Christopher B.
Switzerland, Geneva
Organisation Mondiale de la Santé
Phiri, Amos J.
Malawi, Zomba
University of Malawi
Molyneux, Elizabeth M.
Malawi, Zomba
University of Malawi
Molyneux, Malcolm Edward
Malawi, Zomba
University of Malawi
Statistics
Citations: 83
Authors: 12
Affiliations: 6
Identifiers
Doi:
10.1016/j.vaccine.2006.05.076
ISSN:
0264410X
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Malawi