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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Cryptosporidium hominis Subtypes and Enterocytozoon bieneusi Genotypes in HIV-Infected Persons in Ibadan, Nigeria
Zoonoses and Public Health, Volume 61, No. 4, Year 2014
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Description
Cryptosporidium and Enterocytozoon are common opportunistic pathogens in HIV+ patients in developing countries, especially those do not have access to antiretroviral therapy. To determine the distribution of genotypes/subtypes of Cryptosporidium and Enterocytozoon bieneusi, faecal specimens were collected from 132 HIV+ persons attending a tertiary hospital in Ibadan, Nigeria. By polymerase chain reaction, eight and ten patients were identified as positive for Cryptosporidium spp. and E. bieneusi, respectively. Seven of the Cryptosporidium specimens were identified as C. hominis, while the remaining one as the new species C. viatorum recently identified in the United Kingdom. DNA sequencing of the 60-kDa glycoprotein gene showed that the C. hominis belonged to three common subtype families: Ia (in three patients), Ib (in one patient) and Ie (in one patient). In contrast, DNA sequencing of the E. bieneusi internal transcribed spacer products showed the occurrence of genotypes associated with both humans (Peru 8 in one patient, Nig2 in two patients and a new genotype in one patient) and animals (D in one patient and Type IV in five patients). Low CD4+ cell count was identified as a risk factor for both cryptosporidiosis and microsporidiosis. © 2013 Blackwell Verlag GmbH.
Authors & Co-Authors
Ayinmode, Adekunle Bamidele
Nigeria, Ibadan
College of Medicine, University of Ibadan
Zhang, Hongwei
China, Beijing
Chinese Center for Disease Control and Prevention
Dada-Adegbola, Hannah Odunola
Nigeria, Ibadan
University College Hospital, Ibadan
Xiao, Lihua
United States, Atlanta
National Center for Emerging and Zoonotic Infectious Diseases
Statistics
Citations: 48
Authors: 4
Affiliations: 4
Identifiers
Doi:
10.1111/zph.12072
ISSN:
18631959
e-ISSN:
18632378
Research Areas
Genetics And Genomics
Health System And Policy
Infectious Diseases
Study Locations
Nigeria