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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
BCG vaccination in patients with severe combined immunodeficiency: Complications, risks, and vaccination policies
Journal of Allergy and Clinical Immunology, Volume 133, No. 4, Year 2014
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Description
Background Severe combined immunodeficiency (SCID) is a syndrome characterized by profound T-cell deficiency. BCG vaccine is contraindicated in patients with SCID. Because most countries encourage BCG vaccination at birth, a high percentage of patients with SCID are vaccinated before their immune defect is detected. Objectives We sought to describe the complications and risks associated with BCG vaccination in patients with SCID. Methods An extensive standardized questionnaire evaluating complications, therapeutics, and outcomes regarding BCG vaccination in patients given a diagnosis of SCID was widely distributed. Summary statistics and association analysis was performed. Results Data on 349 BCG-vaccinated patients with SCID from 28 centers in 17 countries were analyzed. Fifty-one percent of the patients had BCG-associated complications, 34% disseminated and 17% localized (a 33,000- and 400-fold increase, respectively, over the general population). Patients receiving early vaccination (≥1 month) showed an increased prevalence of complications (P =.006) and death caused by BCG-associated complications (P <.0001). The odds of experiencing complications among patients with T-cell numbers of 250/μL or less at diagnosis was 2.1 times higher (95% CI, 1.4-3.4 times higher; P =.001) than among those with T-cell numbers of greater than 250/μL. BCG-associated complications were reported in 2 of 78 patients who received antimycobacterial therapy while asymptomatic, and no deaths caused by BCG-associated complications occurred in this group. In contrast, 46 BCG-associated deaths were reported among 160 patients treated with antimycobacterial therapy for a symptomatic BCG infection (P<.0001). Conclusions BCG vaccine has a very high rate of complications in patients with SCID, which increase morbidity and mortality rates. Until safer and more efficient antituberculosis vaccines become available, delay in BCG vaccination should be considered to protect highly vulnerable populations from preventable complications. © 2013 American Academy of Allergy, Asthma & Immunology.
Authors & Co-Authors
Marciano, Beatriz E.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Huang, Chiungyu
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Joshi, Gyan
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Rezaei, Nima
Iran, Tehran
Tehran University of Medical Sciences
Costa-Carvalho, Beatriz Tavares
Brazil, Sao Paulo
Universidade Federal de São Paulo
Allwood, Zoe
United Kingdom, London
Great Ormond Street Hospital for Children Nhs Foundation Trust
Ikincioǧullarí, Aydan İ.
Turkey, Ankara
Ankara Üniversitesi
Reda, Shereen Medhat
Egypt, Cairo
Ain Shams University Children's Hospital
Gennery, Andrew R.
United Kingdom, Newcastle
Great North Children's Hospital
Thon, Vojtech
Czech Republic, Brno
Fakultní Nemocnice u Sv. Anny V Brně
Espinosa-Rosales, Francisco
Mexico, Mexico
Instituto Nacional de Pediatría
Al-Herz, Waleed
Kuwait, Kuwait City
Kuwait University
Porras, Oscar
Costa Rica, San Jose
National Children's Hospital Dr. Carlos Sáenz Herrera
Shcherbina, Anna Yu
Russian Federation, Moscow
Federal Clinical Research Centre for Pediatric Hematology, Oncology and Immunology
Szaflarska, Anna
Poland, Krakow
Szpital Uniwersytecki w Krakowie
Kiliç, Sara Şebnem
Turkey, Bursa
Bursa Uludağ Üniversitesi
Franco, Josè Luis
Colombia, Medellin
Universidad de Antioquia
Gómez Raccio, Andrea C.
Argentina, Buenos Aires
Hospital de Ninos Ricardo Gutierrez
Roxo, Persio
Brazil, Sao Paulo
Universidade de São Paulo
Esteves, Isabel Castro
Portugal, Lisbon
Santa Maria Hospital, Lisbon
Galal, Nermeen Mouftah
Egypt, Giza
Cairo University
Grumach, Anete Sevciovic G.
Brazil, Santo Andre
Centro Universitário Fmabc
Al-Tamemi, Salem Hamdan
Oman, Muscat
Sultan Qaboos University Hospital
Yildiran, Alisan
Turkey, Samsun
Ondokuz Mayis Üniversitesi
Orellana, Julio C.
Argentina, Cordoba
Children's Hospital la Santísima Trinidad
Yamada, Masafumi
Japan, Sapporo
Graduate School of Medicine
Morio, Tomohiro
Japan, Tokyo
Tokyo Medical and Dental University
Liberatore, Diana
Argentina, Buenos Aires
Instituto Universitario Del Hospital Italiano de Buenos Aires
Ohtsuka, Yoshitoshi
Japan, Nishinomiya
Hyogo Medical University
Lau, Yu Lung
Hong Kong
The University of Hong Kong Li ka Shing Faculty of Medicine
Nishikomori, Ryuta
Japan, Kyoto
Kyoto University Hospital
Torres-Lozano, Carlos
Mexico, Guadalajara
Western National Medical Center
Mazzucchelli, Juliana T.L.
Brazil, Sao Paulo
Universidade Federal de São Paulo
Vilela, Maria M.S.
Brazil, Sao Paulo
Universidade Federal de São Paulo
Tavares, Fabiola S.
Brazil, Sao Paulo
Universidade Federal de São Paulo
Cunha, Luciana
Brazil, Belo Horizonte
Universidade Federal de Minas Gerais
Pinto, Jorge Andrade
Brazil, Belo Horizonte
Universidade Federal de Minas Gerais
Espinosa-Padilla, Sara Elva
Mexico, Mexico
Instituto Nacional de Pediatría
Hernandez-Nieto, Leticia
Mexico, Mexico
Instituto Nacional de Pediatría
Elfeky, Reem Ahmed
Egypt, Cairo
Ain Shams University Children's Hospital
Ariga, Tadashi
Japan, Sapporo
Graduate School of Medicine
Heike, Toshio
Japan, Kyoto
Kyoto University Hospital
Dogu, F. E.
Turkey, Ankara
Ankara Üniversitesi
Cipe, Funda
Turkey, Ankara
Ankara Üniversitesi
Formankova, Renata
Czech Republic, Prague
Fakultní Nemocnice V Motole
Nuñez-Nuñez, M. Enriqueta
Mexico, Guadalajara
Western National Medical Center
Bezrodnik, Liliana
Argentina, Buenos Aires
Hospital de Ninos Ricardo Gutierrez
Marques, Jose Gonçalo
Portugal, Lisbon
Santa Maria Hospital, Lisbon
Pereira, María I.
Argentina, Cordoba
Children's Hospital la Santísima Trinidad
Listello, Viviana
Argentina, Cordoba
Children's Hospital la Santísima Trinidad
Slatter, Mary Anne
United Kingdom, Newcastle
Great North Children's Hospital
Nademi, Zohreh
United Kingdom, Newcastle
Great North Children's Hospital
Kowalczyk, Danuta
Poland, Krakow
Szpital Uniwersytecki w Krakowie
Fleisher, Thomas A.
United States, Bethesda
National Institutes of Health Nih
Davies, Graham E.
United Kingdom, London
Great Ormond Street Hospital for Children Nhs Foundation Trust
Neven, Bénédicte
France, Paris
Hôpital Necker Enfants Malades
Rosenzweig, Sergio Damian
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Statistics
Citations: 200
Authors: 57
Affiliations: 34
Identifiers
Doi:
10.1016/j.jaci.2014.02.028
ISSN:
00916749
e-ISSN:
10976825
Study Design
Cross Sectional Study