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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Anti-inflammatory activity of methyl palmitate and ethyl palmitate in different experimental rat models
Toxicology and Applied Pharmacology, Volume 264, No. 1, Year 2012
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Description
Methyl palmitate (MP) and ethyl palmitate (EP) are naturally occurring fatty acid esters reported as inflammatory cell inhibitors. In the current study, the potential anti-inflammatory activity of MP and EP was evaluated in different experimental rat models. Results showed that MP and EP caused reduction of carrageenan-induced rat paw edema in addition to diminishing prostaglandin E2 (PGE2) level in the inflammatory exudates. In lipopolysaccharide (LPS)-induced endotoxemia in rats, MP and EP reduced plasma levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). MP and EP decreased NF-κB expression in liver and lung tissues and ameliorated histopathological changes caused by LPS. Topical application of MP and EP reduced ear edema induced by croton oil in rats. In the same animal model, MP and EP reduced neutrophil infiltration, as indicated by decreased myeloperoxidase (MPO) activity. In conclusion, this study demonstrates the effectiveness of MP and EP in combating inflammation in several experimental models. © 2012 Elsevier Inc..
Authors & Co-Authors
Saeed, Noha M.
Egypt, Badr
Faculty of Pharmacy
El-Demerdash, Ebtehal
Egypt, Cairo
Faculty of Pharmacy - Ain Shams University
Abdel-Rahman, Hanaa M.
Egypt, Badr
Faculty of Pharmacy
Algandaby, Mardi Mohamed
Saudi Arabia, Jeddah
King Abdulaziz University
Al-Abbasi, Fahad A.
Saudi Arabia, Jeddah
King Abdulaziz University
Abdel-Naim, Ashraf Bahyeldeen
Egypt, Cairo
Faculty of Pharmacy - Ain Shams University
Statistics
Citations: 116
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1016/j.taap.2012.07.020
ISSN:
0041008X
e-ISSN:
10960333
Research Areas
Cancer