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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
The Immune Response to Mycobacterium tuberculosis in HIV-1-Coinfected Persons
Annual Review of Immunology, Volume 36, Year 2018
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Description
Globally, about 36.7 million people were living with HIV infection at the end of 2015. The most frequent infection co-occurring with HIV-1 is Mycobacterium tuberculosis-374,000 deaths per annum are attributable to HIV-tuberculosis, 75%nt; of those occurring in Africa. HIV-1 infection increases the risk of tuberculosis by a factor of up to 26 and alters its clinical presentation, complicates diagnosis and treatment, and worsens outcome. Although HIV-1-induced depletion of CD4+ T cells underlies all these effects, more widespread immune deficits also contribute to susceptibility and pathogenesis. These defects present a challenge to understand and ameliorate, but also an opportunity to learn and optimize mechanisms that normally protect people against tuberculosis. The most effective means to prevent and ameliorate tuberculosis in HIV-1-infected people is antiretroviral therapy, but this may be complicated by pathological immune deterioration that in turn requires more effective host-directed anti-inflammatory therapies to be derived. © Copyright 2018 by Annual Reviews. All rights reserved.
Authors & Co-Authors
Esmail, Hanif G.
South Africa, Cape Town
Wellcome Centre for Infectious Diseases Research in Africa
United Kingdom, London
Imperial College London
United Kingdom, Oxford
University of Oxford
Riou, Catherine
South Africa, Cape Town
Wellcome Centre for Infectious Diseases Research in Africa
Bruyn, Elsa Du
South Africa, Cape Town
Wellcome Centre for Infectious Diseases Research in Africa
Lai, Rachel Pei Jen
United Kingdom, London
The Francis Crick Institute
Harley, Yolande X.R.
South Africa, Cape Town
Wellcome Centre for Infectious Diseases Research in Africa
Meintjes, Graeme Ayton
South Africa, Cape Town
Wellcome Centre for Infectious Diseases Research in Africa
Andrea Wilkinson, Katalin Andrea
South Africa, Cape Town
Wellcome Centre for Infectious Diseases Research in Africa
United Kingdom, London
The Francis Crick Institute
Wilkinson, Robert J.
South Africa, Cape Town
Wellcome Centre for Infectious Diseases Research in Africa
United Kingdom, London
Imperial College London
United Kingdom, London
The Francis Crick Institute
Statistics
Citations: 64
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1146/annurev-immunol-042617-053420
ISSN:
07320582
Research Areas
Infectious Diseases