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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
High dose Erythropoietin increases Brain Tissue Oxygen Tension in Severe Vasospasm after Subarachnoid Hemorrhage
BMC Neurology, Volume 12, Article 32, Year 2012
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Description
Background: Vasospasm-related delayed cerebral ischemia (DCI) significantly impacts on outcome after aneurysmal subarachnoid hemorrhage (SAH). Erythropoietin (EPO) may reduce the severity of cerebral vasospasm and improve outcome, however, underlying mechanisms are incompletely understood. In this study, the authors aimed to investigate the effect of EPO on cerebral metabolism and brain tissue oxygen tension (PbtO2).Methods: Seven consecutive poor grade SAH patients with multimodal neuromonitoring (MM) received systemic EPO therapy (30.000 IU per day for 3 consecutive days) for severe cerebral vasospasm. Cerebral perfusion pressure (CPP), mean arterial blood pressure (MAP), intracranial pressure (ICP), PbtO2 and brain metabolic changes were analyzed during the next 24 hours after each dose given. Statistical analysis was performed with a mixed effects model.Results: A total of 22 interventions were analyzed. Median age was 47 years (32-68) and 86 % were female. Three patients (38 %) developed DCI. MAP decreased 2 hours after intervention (P < 0.04) without significantly affecting CPP and ICP. PbtO2 significantly increased over time (P < 0.05) to a maximum of 7 ± 4 mmHg increase 16 hours after infusion. Brain metabolic parameters did not change over time.Conclusions: EPO increases PbtO2 in poor grade SAH patients with severe cerebral vasospasm. The effect on outcome needs further investigation. © 2012 Helbok et al.; licensee BioMed Central Ltd.
Authors & Co-Authors
Helbok, Raimund
Austria, Innsbruck
Medizinische Universitat Innsbruck
Shaker, Ehab
Austria, Innsbruck
Medizinische Universitat Innsbruck
Egypt, Cairo
Faculty of Medicine
Beer, Ronny
Austria, Innsbruck
Medizinische Universitat Innsbruck
Chemelli, Andreas
Austria, Innsbruck
Medizinische Universitat Innsbruck
Sojer, Martin
Austria, Innsbruck
Medizinische Universitat Innsbruck
Sohm, Florian
Austria, Innsbruck
Medizinische Universitat Innsbruck
Broessner, Gregor
Austria, Innsbruck
Medizinische Universitat Innsbruck
Lackner, Peter
Austria, Innsbruck
Medizinische Universitat Innsbruck
Beck, Monika
Austria, Innsbruck
Medizinische Universitat Innsbruck
Zangerle, Alexandra
Austria, Innsbruck
Medizinische Universitat Innsbruck
Pfausler, Bettina E.
Austria, Innsbruck
Medizinische Universitat Innsbruck
Thomé, Claudius
Austria, Innsbruck
Medizinische Universitat Innsbruck
Schmutzhard, Erich
Austria, Innsbruck
Medizinische Universitat Innsbruck
Statistics
Citations: 23
Authors: 13
Affiliations: 2
Identifiers
Doi:
10.1186/1471-2377-12-32
e-ISSN:
14712377
Research Areas
Noncommunicable Diseases
Study Design
Randomised Control Trial
Study Approach
Quantitative
Participants Gender
Female